The role of extracellular vesicles in cancer

R Kalluri, KM McAndrews - Cell, 2023 - cell.com
Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

Harnessing extracellular vesicle heterogeneity for diagnostic and therapeutic applications

RP Carney, RR Mizenko, BT Bozkurt, N Lowe… - Nature …, 2024 - nature.com
Extracellular vesicles (EVs) are diverse nanoparticles with large heterogeneity in size and
molecular composition. Although this heterogeneity provides high diagnostic value for liquid …

Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma–Contributions of platelet extracellular vesicles in plasma samples

N Karimi, R Dalirfardouei, T Dias… - Journal of …, 2022 - Wiley Online Library
Background: The ability to isolate extracellular vesicles (EVs) from blood is vital in the
development of EVs as disease biomarkers. Both serum and plasma can be used, but few …

Clinical translation of extracellular vesicles

A Ghodasara, A Raza, J Wolfram… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) occur in a variety of bodily fluids and have gained recent
attraction as natural materials due to their bioactive surfaces, internal cargo, and role in …

A journey of challenges and victories: a bibliometric worldview of nanomedicine since the 21st century

J Wang, W Zhao, Z Zhang, X Liu, T **e… - Advanced …, 2024 - Wiley Online Library
Nanotechnology profoundly affects the advancement of medicine. Limitations in diagnosing
and treating cancer and chronic diseases promote the growth of nanomedicine. However …

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

W Zheng, J Rädler, H Sork, Z Niu, S Roudi… - Nature …, 2023 - nature.com
Extracellular vesicles (EVs) are gaining ground as next-generation drug delivery modalities.
Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability …

Extracellular vesicle-based liquid biopsy biomarkers and their application in precision immuno-oncology

K Asleh, V Dery, C Taylor, M Davey… - Biomarker …, 2023 - Springer
While the field of precision oncology is rapidly expanding and more targeted options are
revolutionizing cancer treatment paradigms, therapeutic resistance particularly to …

Molecular stratification and treatment monitoring of lung cancer using a small extracellular vesicle-activated nanocavity architecture

J Li, M Li, A Wuethrich, R Guan, L Zhao, C Hu… - Analytical …, 2024 - ACS Publications
Development of molecular diagnostics for lung cancer stratification and monitoring is crucial
for the rational planning and timely adjustment of treatments to improve clinical outcomes. In …

Potentiality of exosomal proteins as novel cancer biomarkers for liquid biopsy

C Hu, W Jiang, M Lv, S Fan, Y Lu, Q Wu… - Frontiers in …, 2022 - frontiersin.org
Liquid biopsy has been rapidly developed in recent years due to its advantages of non-
invasiveness and real-time sampling in cancer prognosis and diagnosis. Exosomes are …

Surface protein profiling of milk and serum extracellular vesicles unveils body fluid-specific signatures

A Giovanazzi, MJC van Herwijnen, M Kleinjan… - Scientific Reports, 2023 - nature.com
Cell-derived extracellular vesicles (EVs) are currently in the limelight as potential disease
biomarkers. The promise of EV-based liquid biopsy resides in the identification of specific …