Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …

Aggressive and recurrent gynecological cancers are associated with worse prognosis and a
lack of effective therapeutic response. Ovarian cancer (OC) patients are often diagnosed in …

Abstract Inhibitors of Apoptosis proteins (IAPs) were discovered through experiments aimed
at rescuing apoptosis in insects. Classically associated with the inhibition of apoptosis, the …

Background: Gliomas are the most malignant tumors of the central nervous system. One of
the factors in their high drug resistance is avoiding programmed death (PCD) induction. This …

Plant secondary metabolites (SMs) common natural occurrences and the significantly lower
toxicities of many SM have led to the approaching development and use of these …

Background Therapeutic resistance fails cancer treatment. Drug-nanoparticle combinations
overcome resistance. Sanguinarine-conjugated nanoparticles may boost sanguinarine's …

Tamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-
menopausal women. Its journey from a failing contraceptive to a blockbuster is an example …

The aim of the study was to investigate the anticancer potential of LY294002 (PI3K inhibitor)
and temozolomide using glioblastoma multiforme (T98G) and anaplastic astrocytoma …

The hormonal luminal-A is the most pre-dominant sub type of breast cancer (BC), and it is
associated with a high level of cyclin D1 in Saudi patients. Tamoxifen is the golden therapy …