Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics

S Prabha, M Sajad, GM Hasan, A Islam… - Ageing research …, 2024 - Elsevier
Alzheimer's disease (AD) is a significant neocortical degenerative disorder characterized by
the progressive loss of neurons and secondary alterations in white matter tracts …

Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases

Z Yang, R Feng, H Zhao - Apoptosis, 2024 - Springer
Cuproptosis, a newly characterized form of regulated cell death driven by copper
accumulation, has emerged as a significant mechanism underlying various non-cancerous …

Heavy metals exposure and Alzheimer's disease: Underlying mechanisms and advancing therapeutic approaches

NA Althobaiti - Behavioural Brain Research, 2024 - Elsevier
Heavy metals such as lead, cadmium, mercury, and arsenic are prevalent in the
environment due to both natural and anthropogenic sources, leading to significant public …

Molecular interactions, structural effects, and binding affinities between silver ions (Ag+) and amyloid beta (Aβ) peptides

AL Lakela, E Berntsson, F Vosough, J Jarvet, S Paul… - Scientific Reports, 2025 - nature.com
Because silver is toxic to microbes, but not considered toxic to humans, the metal has been
used as an antimicrobial agent since ancient times. Today, silver nanoparticles and colloidal …

Targeting biometals in Alzheimer's disease with metal chelating agents including coumarin derivatives

A Gucký, S Hamuľaková - CNS drugs, 2024 - Springer
Numerous physiological processes happening in the human body, including cerebral
development and function, require the participation of biometal ions such as iron, copper …

Zeolite and neurodegenerative diseases

S Panaiotov, L Tancheva, R Kalfin, P Petkova-Kirova - Molecules, 2024 - mdpi.com
Neurodegenerative diseases (NDs), characterized by progressive degeneration and death
of neurons, are strongly related to aging, and the number of people with NDs will continue to …

Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies

V Das, JH Miller, CG Alladi, N Annadurai… - Medicinal Research …, 2024 - Wiley Online Library
As the world population ages, there will be an increasing need for effective therapies for
aging‐associated neurodegenerative disorders, which remain untreatable. Dementia due to …

Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials

D Huang, W Liao, J Li, T Chen, X Wang… - Advanced Functional …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease that
constitutes the third most common cause of death among elderly individuals. AD patients …

Nanomedicine targets endogenous copper ions for disease diagnosis and therapy

X Li, Y Cui, T Zhou, J Li, P Lu, L Yuwen, L Wang… - Chemical Engineering …, 2023 - Elsevier
Copper ion is an essential microelement that plays vital roles in a wide range of
physiological processes, and aberrant copper levels in vivo usually cause various diseases …

[HTML][HTML] Bioinorganic chemistry of micronutrients related to Alzheimer's and Parkinson's diseases

A Kola, F Nencioni, D Valensin - Molecules, 2023 - mdpi.com
Metal ions are fundamental to guarantee the regular physiological activity of the human
organism. Similarly, vitamins play a key role in many biological functions of the metabolism …