[HTML][HTML] Pulmonary delivery of biological drugs

W Liang, HW Pan, D Vllasaliu, JKW Lam - Pharmaceutics, 2020 - mdpi.com
In the last decade, biological drugs have rapidly proliferated and have now become an
important therapeutic modality. This is because of their high potency, high specificity and …

Viral emerging diseases: challenges in develo** vaccination strategies

M Trovato, R Sartorius, L D'Apice, R Manco… - Frontiers in …, 2020 - frontiersin.org
In the last decades, a number of infectious viruses have emerged from wildlife or re-
emerged, generating serious threats to the global health and to the economy worldwide …

Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2

Y **ang, S Nambulli, Z **ao, H Liu, Z Sang, WP Duprex… - Science, 2020 - science.org
Cost-effective, efficacious therapeutics are urgently needed to combat the COVID-19
pandemic. In this study, we used camelid immunization and proteomics to identify a large …

An update of anti-viral treatment of COVID-19.

S ŞİMŞEK YAVUZ… - Turkish journal of …, 2021 - search.ebscohost.com
Background/aim: Currently there is not an effective antiviral treatment for COVID-19, but a
large number of drugs have been evaluated since the beginning of the pandemic, and many …

Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

S Nambulli, Y **ang, NL Tilston-Lunel, LJ Rennick… - Science …, 2021 - science.org
Globally, there is an urgency to develop effective, low-cost therapeutic interventions for
coronavirus disease 2019 (COVID-19). We previously generated the stable and ultrapotent …

[HTML][HTML] The find of COVID-19 vaccine: Challenges and opportunities

M ElBagoury, MM Tolba, HA Nasser, A Jabbar… - Journal of infection and …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus (SARS-CoV-2), a novel corona virus,
causing COVID-19 with Flu-like symptoms is the first alarming pandemic of the third …

Keep out! SARS-CoV-2 entry inhibitors: their role and utility as COVID-19 therapeutics

L Chitsike, P Duerksen-Hughes - Virology Journal, 2021 - Springer
The COVID-19 pandemic has put healthcare infrastructures and our social and economic
lives under unprecedented strain. Effective solutions are needed to end the pandemic while …

Nano-engineered tools in the diagnosis, therapeutics, prevention, and mitigation of SARS-CoV-2

S Kamat, M Kumari, C Jayabaskaran - Journal of Controlled Release, 2021 - Elsevier
The recent outbreak of SARS-CoV-2 has forever altered mankind resulting in the COVID-19
pandemic. This respiratory virus further manifests into vital organ damage, resulting in …

[HTML][HTML] Quantum leap of monoclonal antibody (mAb) discovery and development in the COVID-19 era

S Pecetta, O Finco, A Seubert - Seminars in immunology, 2020 - Elsevier
In recent years the global market for monoclonal antibodies (mAbs) became a multi-billion-
dollar business. This success is mainly driven by treatments in the oncology and …

A comprehensive comparison between camelid nanobodies and single chain variable fragments

Y Asaadi, FF Jouneghani, S Janani… - Biomarker Research, 2021 - Springer
By the emergence of recombinant DNA technology, many antibody fragments have been
developed devoid of undesired properties of natural immunoglobulins. Among them …