Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …

The somatic mutations in each cancer genome are caused by multiple mutational
processes, each of which leaves a characteristic imprint (or 'signature'), potentially caused …

While prime editing enables precise sequence changes in DNA, cellular determinants of
prime editing remain poorly understood. Using pooled CRISPRi screens, we discovered that …

Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses,
revealing mutational signatures, imprints of DNA damage, and repair processes that have …

Prime editing (PE) is a powerful genome engineering approach that enables the introduction
of base substitutions, insertions and deletions into any given genomic locus. However, the …

The rates and patterns of somatic mutation in normal tissues are largely unknown outside of
humans,,,,,–. Comparative analyses can shed light on the diversity of mutagenesis across …

The chemotherapeutic agent CX-5461, or pidnarulex, has been fast-tracked by the United
States Food and Drug Administration for early-stage clinical studies of BRCA1-, BRCA2-and …

C-to-T transitions in CpG dinucleotides are the most prevalent mutations in human cancers
and genetic diseases. These mutations have been attributed to deamination of 5 …

Transmissible cancers are malignant cell lineages that spread clonally between individuals.
Several such cancers, termed bivalve transmissible neoplasia (BTN), induce leukemia-like …

Mismatch repair (MMR)-deficient cancer evolves through the stepwise erosion of coding
homopolymers in target genes. Curiously, the MMR genes MutS homolog 6 (MSH6) and …