Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

M Vallet-Regí, F Schüth, D Lozano, M Colilla… - Chemical Society …, 2022 - pubs.rsc.org
The present review details a chronological description of the events that took place during
the development of mesoporous materials, their different synthetic routes and their use as …

Environmental factors influencing the development and spread of antibiotic resistance

J Bengtsson-Palme, E Kristiansson… - FEMS microbiology …, 2018 - academic.oup.com
Antibiotic resistance and its wider implications present us with a growing healthcare crisis.
Recent research points to the environment as an important component for the transmission …

Chemically engineered mesoporous silica nanoparticles-based intelligent delivery systems for theranostic applications in multiple cancerous/non-cancerous diseases

S Zhou, Q Zhong, Y Wang, P Hu, W Zhong… - Coordination Chemistry …, 2022 - Elsevier
In recent years, the unprecedented advances of biomedical nanotechnology have spurred
the development of drug delivery systems (DDSs) based on multifarious nanomaterials in …

Next-generation approaches to understand and combat the antibiotic resistome

TS Crofts, AJ Gasparrini, G Dantas - Nature Reviews Microbiology, 2017 - nature.com
Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …

Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes

S Khedkar, G Smyshlyaev, I Letunic… - Nucleic Acids …, 2022 - academic.oup.com
Abstract Prokaryotic Mobile Genetic Elements (MGEs) such as transposons, integrons,
phages and plasmids, play important roles in prokaryotic evolution and in the dispersal of …

What is a resistance gene? Ranking risk in resistomes

JL Martínez, TM Coque, F Baquero - Nature Reviews Microbiology, 2015 - nature.com
Metagenomic studies have shown that antibiotic resistance genes are ubiquitous in the
environment, which has led to the suggestion that there is a high risk that these genes will …

Evolutionary pathways and trajectories in antibiotic resistance

F Baquero, JL Martinez, V F. Lanza… - Clinical Microbiology …, 2021 - journals.asm.org
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …

Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions

G Cox, GD Wright - International Journal of Medical Microbiology, 2013 - Elsevier
The intrinsic antibiotic resistome is a naturally occurring phenomenon that predates
antibiotic chemotherapy and is present in all bacterial species. In addition to the intrinsic …

Origins and evolution of antibiotic resistance

J Davies, D Davies - Microbiology and molecular biology reviews, 2010 - journals.asm.org
Antibiotics have always been considered one of the wonder discoveries of the 20th century.
This is true, but the real wonder is the rise of antibiotic resistance in hospitals, communities …

Challenges of antibacterial discovery

LL Silver - Clinical microbiology reviews, 2011 - journals.asm.org
The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …