Despite its complexity, blood is probably the best understood developmental system, largely
due to seminal experimentation in the mouse. Clinically, hematopoietic stem cell (HSC) …

The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

The culmination of decades of research on humanized mice is leading to advances in our
understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity …

Although uncontrolled proliferation is a distinguishing property of a tumor as a whole, the
individual cells that make up the tumor exhibit considerable variation in many properties …

The efficient generation of hematopoietic stem cells from human pluripotent stem cells is
dependent on the appropriate specification of the definitive hematopoietic program during …

Hematopoietic stem cells (HSCs) develop during embryogenesis in a complex process that
involves multiple anatomical sites. Once HSC precursors have been specified from …

Human pluripotent stem cells (hPSCs) represent a promising source of patient-specific cells
for disease modeling, drug screens, and cellular therapies. However, the inability to derive …

In vertebrates, the first haematopoietic stem cells (HSCs) with multi-lineage and long-term
repopulating potential arise in the AGM (aorta–gonad–mesonephros) region. These HSCs …

Background Human embryonic stem cells (hESC) should enable novel insights into early
human development and provide a renewable source of cells for regenerative medicine …

In vitro generation of hematopoietic stem cells (HSCs) from induced pluripotent stem cells
(iPSCs) has the potential to provide novel therapeutic approaches for replacing bone …