Advances in imaging are transforming our understanding of angiogenesis and the
evaluation of drugs that stimulate or inhibit angiogenesis in preclinical models and human …

This review assembles the laboratory and clinical evidence that cytotoxic chemotherapy and
antiangiogenic therapy are each dependent on endothelial cell apoptosis. During cytotoxic …

Drug development is a long process that generally spans about 10 to 15 years. The shift in
recent drug discovery to novel agents against specific molecular targets highlights the need …

The development of anticancer therapies that target the angiogenic process is an area of
major growth in oncology. A method of noninvasively measuring tumor vascular endothelial …

Specific internalization of endostatin into endothelial cells has been proved to be important
for its biologic functions. However, the mechanism of endostatin internalization still remains …

Epidermal growth factor receptor (EGFR) plays an important role in cell division and cancer
progression, as well as angiogenesis and metastasis. Since many tumor cells exhibit the …

Improvement of scintigraphic tumor imaging is extensively determined by the development
of more tumor specific radiopharmaceuticals. Thus, to improve the differential diagnosis …

Purpose: The aim of this study was to evaluate 99mTc-ethylenedicysteine-glucosamine (EC-
DG) for the assessment of tumor growth. Method: To evaluate whether 99mTc-EC-DG is …

Retention of lipoproteins to proteoglycans in the subendothelial matrix (SEM) is an early
event in atherosclerosis. We recently reported that collagen XVIII and its proteolytically …

Direct radiolabeling of proteins can result in the loss of targeting activity, requires highly
customized procedures, and yields heterogeneous products. Here we describe a novel …