Alternative splicing and evolution: diversification, exon definition and function
H Keren, G Lev-Maor, G Ast - Nature Reviews Genetics, 2010 - nature.com
Over the past decade, it has been shown that alternative splicing (AS) is a major mechanism
for the enhancement of transcriptome and proteome diversity, particularly in mammals …
for the enhancement of transcriptome and proteome diversity, particularly in mammals …
The origin of new genes: glimpses from the young and old
Genome data have revealed great variation in the numbers of genes in different organisms,
which indicates that there is a fundamental process of genome evolution: the origin of new …
which indicates that there is a fundamental process of genome evolution: the origin of new …
Global impact of unproductive splicing on human gene expression
Alternative splicing (AS) in human genes is widely viewed as a mechanism for enhancing
proteomic diversity. AS can also impact gene expression levels without increasing protein …
proteomic diversity. AS can also impact gene expression levels without increasing protein …
Crystal structure of the lactose operon repressor and its complexes with DNA and inducer
M Lewis, G Chang, NC Horton, MA Kercher, HC Pace… - Science, 1996 - science.org
The lac operon of Escherichia coli is the paradigm for gene regulation. Its key component is
the lac repressor, a product of the lacI gene. The three-dimensional structures of the intact …
the lac repressor, a product of the lacI gene. The three-dimensional structures of the intact …
The evolution of spliceosomal introns: patterns, puzzles and progress
S William Roy, W Gilbert - Nature Reviews Genetics, 2006 - nature.com
The origins and importance of spliceosomal introns comprise one of the longest-abiding
mysteries of molecular evolution. Considerable debate remains over several aspects of the …
mysteries of molecular evolution. Considerable debate remains over several aspects of the …
[HTML][HTML] Cytochromes P450
There are 244 cytochrome P450 genes (and 28 pseudogenes) in the Arabidopsis genome.
P450s thus form one of the largest gene families in plants. Contrary to what was initially …
P450s thus form one of the largest gene families in plants. Contrary to what was initially …
Recurrent evolution of vertebrate transcription factors by transposase capture
RL Cosby, J Judd, R Zhang, A Zhong, N Garry… - Science, 2021 - science.org
INTRODUCTION How novel protein architectures evolve remains poorly understood. The
rearrangement of domains with preexisting functions into new composite architectures …
rearrangement of domains with preexisting functions into new composite architectures …
Intron—exon structures of eukaryotic model organisms
M Long, M Deutsch - Nucleic acids research, 1999 - academic.oup.com
To investigate the distribution of intron—exon structures of eukaryotic genes, we have
constructed a general exon database comprising all available introncontaining genes and …
constructed a general exon database comprising all available introncontaining genes and …
New gene evolution: little did we know
Genes are perpetually added to and deleted from genomes during evolution. Thus, it is
important to understand how new genes are formed and how they evolve to be critical …
important to understand how new genes are formed and how they evolve to be critical …
Where the minor things are: a pan-eukaryotic survey suggests neutral processes may explain much of minor intron evolution
Spliceosomal introns are gene segments removed from RNA transcripts by
ribonucleoprotein machineries called spliceosomes. In some eukaryotes a second …
ribonucleoprotein machineries called spliceosomes. In some eukaryotes a second …