Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide,
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …

Hepatocellular cell death and macrophage proinflammatory activation contribute to the
pathology of various liver diseases, during which XBP1 plays an important role. However …

Conclusions Helper CD4+ T‐cell phenotype and function following HCV viral vectored
vaccination resembles “protective memory” that is observed following spontaneous …

To defense harmful stimuli or maintain the immune homeostasis, the body produces and
recruits a superfamily of cytokines such as interleukins, interferons, chemokines etc. Among …

Despite advances in the treatment of cancers through surgical procedures and new
pharmaceuticals, the treatment of hepatocellular carcinoma (HCC) remains challenging as …

Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular
functions including carbohydrate, lipid and protein metabolism, detoxification and immune …

The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …

Emerging evidence points to a strong association between the gut microbiota and the risk,
development and progression of gastrointestinal cancers such as colorectal cancer (CRC) …