Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

At present more than 250 FDA approved chlorine containing drugs were available in the
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …

The emergence and wide-spread of drug-resistant bacteria including multi-drug resistant
and pan-drug resistant pathogens which are associated with considerable mortality …

Inflammatory mediators of the arachidonic acid cascade from cyclooxygenase (COX) and
lipoxygenase (LOX) pathways are primarily responsible for many diseases in human beings …

A new set of ibuprofen-quinoline conjugates comprising quinolinyl heterocycle and
ibuprofen moieties linked by an alkyl chain were synthesized in good yields utilizing an …

Tuberculosis (TB) remains one of the most widespread and leading deadliest diseases,
around one-third of the world's population harbor a latent infection by Mycobacterium …

Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …

Nitrogen heterocycles play an essential role in medication development. The 1, 2, 4‐
oxadiazole heterocycle has been extensively studied, yielding a large variety of molecules …

A series of newly synthesized 4-aryl-hydrazonopyrazolones were designed and their
structures were confirmed by spectral and elemental analyses. All synthesized compounds …

In this work, a series of novel indole-2-amide compounds were designed, synthesized,
characterized and the anti-inflammatory activity in vivo were evaluated. Compounds 8a, 10b …