The diversity of biomolecules present in plasmid DNA (pDNA)-containing extracts and the
structural and chemical similarities between pDNA and impurities are some of the main …

Research on RNA has led to many important biological discoveries and improvement of
therapeutic technologies. From basic to applied research, many procedures employ pure …

The contributions of plasmids to biology and their impact in biotechnology and discovery
have been immense. Together with restriction enzymes, plasmids were one of the key …

Chromatographic technology is undoubtedly one of the most diverse and powerful
purification methods for downstream process applications. The diversity and quantity of …

Background It is well known that the success of gene transfer to cells and subsequent
expression is strictly affected by the vector manufacturing process. Several challenges …

Plasmid DNA chromatography is a powerful field in constant development and evolution.
The use of this technique is considered mandatory in the production of an efficient and safe …

Minicircles are non-viral delivery vectors with promising features for biopharmaceutical
applications. These vectors are plasmid-derived circular DNA molecules that are obtained in …

The aim of this study is to prepare supermacroporous pseudospecific cryogel which can be
used for the purification of plasmid DNA (pDNA) from bacterial lysate. N-methacryloyl-(l) …

The demand for plasmid DNA in large quantities at high purity and concentration is expected
to escalate as more DNA vaccines are entering clinical trial status and becoming closer to …

The aim of this study is to prepare poly (hydroxyethyl methacrylate-N-methacryloyl-(L)-
histidine)[PHEMAH] magnetic nanoparticles for plasmid DNA (pDNA) purification from …