The role of inflammation in diabetic retinopathy

JV Forrester, L Kuffova, M Delibegovic - Frontiers in immunology, 2020 - frontiersin.org
Inflammation is central to pathogenic processes in diabetes mellitus and the metabolic
syndrome and particularly implicates innate immunity in the development of complications …

[HTML][HTML] Three-dimensional printing of metals for biomedical applications

J Ni, H Ling, S Zhang, Z Wang, Z Peng, C Benyshek… - Materials Today Bio, 2019 - Elsevier
Abstract Three-dimensional (3D) printing technology has received great attention in the past
decades in both academia and industry because of its advantages such as customized …

Role of inflammatory cells in pathophysiology and management of diabetic retinopathy

E Kovoor, SK Chauhan, A Hajrasouliha - Survey of ophthalmology, 2022 - Elsevier
Diabetic retinopathy (DR) is a sight-threatening complication of diabetes mellitus. Several
inflammatory cells and proteins, including macrophages and microglia, cytokines, and …

Eicosanoids and oxidative stress in diabetic retinopathy

MH Wang, G Hsiao, M Al-Shabrawey - Antioxidants, 2020 - mdpi.com
Oxidative stress is an important factor to cause the pathogenesis of diabetic retinopathy (DR)
because the retina has high vascularization and long-time light exposition. Cyclooxygenase …

Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications

AD Dobrian, MA Morris, DA Taylor-Fishwick… - Pharmacology & …, 2019 - Elsevier
lipoxygenase (12-LOX) is one of several enzyme isoforms responsible for the metabolism of
arachidonic acid and other poly-unsaturated fatty acids to both pro-and anti-inflammatory …

WFDC12-overexpressing contributes to the development of atopic dermatitis via accelerating ALOX12/15 metabolism and PAF accumulation

G Li, L Gu, F Zhao, Y Hu, X Wang, F Zeng, J Yu… - Cell Death & …, 2023 - nature.com
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczema-like
skin lesions, dry skin, severe itching, and recurrent recurrence. The whey acidic protein four …

Glyoxalase system as a therapeutic target against diabetic retinopathy

G Aragonès, S Rowan, SG Francisco, W Yang… - Antioxidants, 2020 - mdpi.com
Hyperglycemia, a defining characteristic of diabetes, combined with oxidative stress, results
in the formation of advanced glycation end products (AGEs). AGEs are toxic compounds that …

Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy

K Elmasry, AS Ibrahim, H Saleh, N Elsherbiny… - Diabetologia, 2018 - Springer
Aims/hypothesis Our earlier studies have established the role of 12/15-lipoxygenase (LO) in
mediating the inflammatory reaction in diabetic retinopathy. However, the exact mechanism …

12-HETE activates Müller glial cells: The potential role of GPR31 and miR-29

M Moustafa, A Khalil, NHE Darwish, DQ Zhang… - Prostaglandins & Other …, 2024 - Elsevier
Diabetic retinopathy (DR) is a neurovascular complication of diabetes, driven by an intricate
network of cellular and molecular mechanisms. This study sought to explore the …

Models of retinal diseases and their applicability in drug discovery

G Malek, J Busik, MB Grant… - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: The impact of vision debilitating diseases is a global public health concern,
which will continue until effective preventative and management protocols are developed …