Use of zebrafish in drug discovery toxicology
Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …
health and money. The drug discovery industry attempts to minimize those events with …
Approaches to test the neurotoxicity of environmental contaminants in the zebrafish model: From behavior to molecular mechanisms
JA Fitzgerald, S Könemann… - Environmental …, 2021 - Wiley Online Library
The occurrence of neuroactive chemicals in the aquatic environment is on the rise and
poses a potential threat to aquatic biota of currently unpredictable outcome. In particular …
poses a potential threat to aquatic biota of currently unpredictable outcome. In particular …
[HTML][HTML] Toxicological effects of 6PPD and 6PPD quinone in zebrafish larvae
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is the most widely
used antioxidant in automobile tyres and many rubber products. We investigated the impact …
used antioxidant in automobile tyres and many rubber products. We investigated the impact …
Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) …
Abstract Background The Fish Embryo Acute Toxicity (FET) test with the zebrafish (Danio
rerio) embryo, the OECD test guideline (TG) 236, has been designed as an alternative for …
rerio) embryo, the OECD test guideline (TG) 236, has been designed as an alternative for …
[HTML][HTML] Recommendation on test readiness criteria for new approach methods (NAM) in toxicology: exemplified for developmental neurotoxicity (DNT)
A Bal-Price, HT Hogberg, KM Crofton, M Daneshian… - Altex, 2018 - ncbi.nlm.nih.gov
Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …
such new approach methods (NAMs) in a regulatory context, criteria to define their …
Zebrafish models of neurodevelopmental disorders: limitations and benefits of current tools and techniques
For the past few years there has been an exponential increase in the use of animal models
to confirm the pathogenicity of candidate disease-causing genetic variants found in patients …
to confirm the pathogenicity of candidate disease-causing genetic variants found in patients …
Hypo-or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior …
A Ogungbemi, D Leuthold, S Scholz… - Environmental Sciences …, 2019 - Springer
Tests with zebrafish embryos have gained wide acceptance as an alternative test model for
drug development and toxicity testing. In particular, the behavioral response of the zebrafish …
drug development and toxicity testing. In particular, the behavioral response of the zebrafish …
[HTML][HTML] Assessment of behavioural effects of three water-soluble polymers in zebrafish embryos
The water-soluble polymers (WSPs) are widely used in many industrial applications and are
present in several commonly used products due to their physical-chemical characteristics …
present in several commonly used products due to their physical-chemical characteristics …
Towards improved screening of toxins for Parkinson's risk
Parkinson's disease (PD) is a chronic, progressive and disabling neurodegenerative
disorder. The prevalence of PD has risen considerably over the past decades. A growing …
disorder. The prevalence of PD has risen considerably over the past decades. A growing …
[HTML][HTML] DMSO effects larval zebrafish (Danio rerio) behavior, with additive and interaction effects when combined with positive controls
Embryonic and larval zebrafish (Danio rerio) behavior is commonly used to identify
neurotoxic compounds. Here, we investigated whether sub-lethal exposures to the common …
neurotoxic compounds. Here, we investigated whether sub-lethal exposures to the common …