Computational modeling of realistic cell membranes

SJ Marrink, V Corradi, PCT Souza, HI Ingolfsson… - Chemical …, 2019 - ACS Publications
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

Emerging diversity in lipid–protein interactions

V Corradi, BI Sejdiu, H Mesa-Galloso… - Chemical …, 2019 - ACS Publications
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Receptor tyrosine kinase activation: From the ligand perspective

R Trenker, N Jura - Current opinion in cell biology, 2020 - Elsevier
Receptor tyrosine kinases (RTKs) are single-span transmembrane receptors in which
relatively conserved intracellular kinase domains are coupled to divergent extracellular …

Activation of the EGF receptor by ligand binding and oncogenic mutations: the “rotation model”

ER Purba, E Saita, IN Maruyama - Cells, 2017 - mdpi.com
The epidermal growth factor receptor (EGFR) plays vital roles in cellular processes including
cell proliferation, survival, motility, and differentiation. The dysregulated activation of the …

The RTK interactome: overview and perspective on RTK heterointeractions

MD Paul, K Hristova - Chemical reviews, 2018 - ACS Publications
Receptor tyrosine kinases (RTKs) play important roles in cell growth, motility, differentiation,
and survival. These single-pass membrane proteins are grouped into subfamilies based on …

Eukaryotic cell membranes: structure, composition, research methods and computational modelling

A Zhukov, V Popov - International Journal of Molecular Sciences, 2023 - mdpi.com
This paper deals with the problems encountered in the study of eukaryotic cell membranes.
A discussion on the structure and composition of membranes, lateral heterogeneity of …

Membrane receptor activation mechanisms and transmembrane peptide tools to elucidate them

JM Westerfield, FN Barrera - Journal of Biological Chemistry, 2020 - ASBMB
Single-pass membrane receptors contain extracellular domains that respond to external
stimuli and transmit information to intracellular domains through a single transmembrane …

It takes more than two to tango: Complex, hierarchal, and membrane-modulated interactions in the regulation of receptor tyrosine kinases

T Kovacs, F Zakany, P Nagy - Cancers, 2022 - mdpi.com
Simple Summary Receptor tyrosine kinases probably constitute the most important
subfamily of transmembrane receptors with respect to their role in regulating the balance …

Structural studies providing insights into production and conformational behavior of amyloid-β peptide associated with Alzheimer's disease development

AS Urban, KV Pavlov, AV Kamynina, IS Okhrimenko… - Molecules, 2021 - mdpi.com
Alzheimer's disease is the most common type of neurodegenerative disease in the world.
Genetic evidence strongly suggests that aberrant generation, aggregation, and/or clearance …