Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Sequencing of cell-free DNA in the blood of cancer patients (liquid biopsy) provides
attractive opportunities for early diagnosis, assessment of treatment response, and minimally …

Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genoty** and exome and genome sequencing …

Paediatric solid tumours arise from endodermal, ectodermal, or mesodermal lineages.
Although the overall survival of children with solid tumours is 75%, that of children with …

Developmental tumors in children and young adults carry few genetic alterations, yet they
have diverse clinical presentation. Focusing on Ewing sarcoma, we sought to establish the …

Transcription factors (TFs) are frequently mutated in cancer. Paediatric cancers exhibit few
mutations genome-wide but frequently harbour sentinel mutations that affect TFs, which …

Fusion-transcription factors (fusion-TFs) represent a class of driver oncoproteins that are
difficult to therapeutically target. Recently, protein degradation has emerged as a strategy to …

Background New prognostic markers are needed to identify patients with Ewing sarcoma
(EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the …

Oncogenic fusions formed through chromosomal rearrangements are hallmarks of
childhood cancer that define cancer subtype, predict outcome, persist through treatment …