The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

Catalysis has a central role in organic synthetic methodology, especially in stereoselective
reactions. In many reactions, enantioselectivity is made possible through the use of chiral …

High selectivity and exquisite control over the outcome of reactions entice chemists to use
biocatalysts in organic synthesis. However, many useful reactions are not accessible …

Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Covering: up to July 2023 Terpene cyclases (TCs) catalyze some of the most complicated
reactions in nature and are responsible for creating the skeletons of more than 95 000 …

Directed evolution is a powerful technique for generating tailor-made enzymes for a wide
range of biocatalytic applications. Following the principles of natural evolution, iterative …

Carbon–carbon bond formation is the key reaction for organic synthesis to construct the
carbon framework of organic molecules. The review gives a selection of biocatalytic C–C …

(−)-Ambrox, the most prominent olfactive component of ambergris is one of the most widely
used biodegradable fragrance ingredients. Traditionally it is produced from the diterpene …

Current environmental and safety considerations urge innovation to address the need for
sustainable high‐value chemicals that are embraced by consumers. This review discusses …

The first example of a biocatalytic [2, 3]‐sigmatropic rearrangement reaction involving allylic
sulfides and diazo reagents (Doyle–Kirmse reaction) is reported. Engineered variants of …