Role of oxidative stress in pathophysiology of nonalcoholic fatty liver disease

M Masarone, V Rosato, M Dallio… - Oxidative medicine …, 2018 - Wiley Online Library
Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease
(NAFLD), is a common hepatic condition that encompasses a wide spectrum of …

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

E Buzzetti, M Pinzani, EA Tsochatzis - Metabolism, 2016 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing
challenge in terms of prevention and treatment. Despite its high prevalence, only a small …

[HTML][HTML] Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective

MH Farzaei, M Zobeiri, F Parvizi, FF El-Senduny… - Nutrients, 2018 - mdpi.com
Oxidative stress has been considered a key causing factor of liver damage induced by a
variety of agents, including alcohol, drugs, viral infections, environmental pollutants and …

ROS, cell senescence, and novel molecular mechanisms in aging and age‐related diseases

P Davalli, T Mitic, A Caporali… - … medicine and cellular …, 2016 - Wiley Online Library
The aging process worsens the human body functions at multiple levels, thus causing its
gradual decrease to resist stress, damage, and disease. Besides changes in gene …

Oxidative stress as a crucial factor in liver diseases

H Cichoż-Lach, A Michalak - World journal of …, 2014 - pmc.ncbi.nlm.nih.gov
Redox state constitutes an important background of numerous liver disorders. The redox
state participates in the course of inflammatory, metabolic and proliferative liver diseases …

Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target

D Liu, CC Wong, L Fu, H Chen, L Zhao, C Li… - Science translational …, 2018 - science.org
Nonalcoholic fatty liver disease (NAFLD)–induced hepatocellular carcinoma (HCC) is an
emerging malignancy in the developed world; however, mechanisms that contribute to its …

[HTML][HTML] Progress in nonalcoholic fatty liver disease: SIRT family regulates mitochondrial biogenesis

C Zeng, M Chen - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin
resistance, mitochondrial dysfunction, inflammation, and oxidative stress. As a group of …

Liver diseases and aging: friends or foes?

F Sheedfar, SD Biase, D Koonen, M Vinciguerra - Aging cell, 2013 - Wiley Online Library
The liver is the only internal human organ capable of natural regeneration of lost tissue, as
little as 25% of a liver can regenerate into a whole liver. The process of aging predisposes to …

Non-alcoholic fatty liver disease: From pathogenesis to clinical impact

A Caturano, C Acierno, R Nevola, PC Pafundi… - Processes, 2021 - mdpi.com
Non-Alcoholic Fatty Liver Disease (NAFLD) is caused by the accumulation of fat in over 5%
of hepatocytes in the absence of alcohol consumption. NAFLD is considered the hepatic …

Dihydromyricetin ameliorates nonalcoholic fatty liver disease by improving mitochondrial respiratory capacity and redox homeostasis through modulation of SIRT3 …

X Zeng, J Yang, O Hu, J Huang, L Ran… - Antioxidants & redox …, 2019 - liebertpub.com
Aims: Our previous clinical trial indicated that the flavonoid dihydromyricetin (DHM) could
improve hepatic steatosis in patients with nonalcoholic fatty liver disease (NAFLD), altough …