Peptides derived from proopiomelanocortin (POMC) are well-established neuropeptides
and peptide hormones that perform multiple functions, including regulation of body weight …

The kexin-like proprotein convertases perform the initial proteolytic cleavages that ultimately
generate a variety of different mature peptide and proteins, ranging from brain …

Obesity is one of the main public health problems in Mexico and the world and one from
which a large number of pathologies derive. Single nucleotide polymorphisms (SNPs) of …

Pro-opiomelanocortin (POMC) neurons form an integral part of the central melanocortin
system regulating food intake and energy expenditure. Genetic and pharmacological studies …

Background Genetic background of severe obesity is inadequately understood. The effect of
genetic factors on weight loss after metabolic bariatric surgery (MBS) has shown …

Objective Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are
essential regulators of energy balance. Selective loss of POMC production in these cells …

Objectives The proprotein convertase subtilisin/Kexin type 1 gene (PCSK1) is implicated in
hypothalamic appetite control. Several studies have addressed the relationship between …

PCSK1 encodes an enzyme required for prohormone maturation into bioactive peptides. A
striking number of single nucleotide polymorphisms and rare mutations in PCSK1 are …

El sobrepeso y la obesidad afectan a más 340 millones de niños y adolescentes alrededor
del mundo, lo que constituye un problema grave de salud pública. La obesidad es una …

Proprotein convertases (PCs) are Ca2+-dependent serine endoproteases containing a
catalytic domain homologous to that of bacterial subtilisins and yeast kexin. Therefore, the …