This review addresses the cellular and molecular mechanisms of cadherin-based tissue
morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations …

Actin filaments are major components of at least 15 distinct structures in metazoan cells.
These filaments assemble from a common pool of actin monomers, but do so at different …

In a recently developed human breast cancer model, treatment of tumor cells in a 3-
dimensional culture with inhibitory β1-integrin antibody or its Fab fragments led to a striking …

Epithelial cell-cell junctions, organized by adhesion proteins and the underlying actin
cytoskeleton, are considered to be stable structures maintaining the structural integrity of …

Spatial and functional organization of cells in tissues is determined by cell-cell adhesion,
thought to be initiated through trans-interactions between extracellular domains of the …

ZO-1, a 220-kD peripheral membrane protein consisting of an amino-terminal half discs
large (dlg)-like domain and a carboxyl-terminal half domain, is concentrated at the cadherin …

Matrix metalloproteinases (MMPs) regulate ductal morphogenesis, apoptosis, and
neoplastic progression in mammary epithelial cells. To elucidate the direct effects of MMPs …

The function of many transmembrane molecules can be altered by cleavage and
subsequent release of their ectodomains. We have investigated ectodomain cleavage of the …

E-cadherin controls a wide array of cellular behaviors including cell–cell adhesion,
differentiation and tissue development. Here we show that presenilin-1 (PS1), a protein …

Cadherins comprise a family of calcium‐dependent glycoproteins that function in mediating
cell‐cell adhesion in virtually all solid tissues of multicellular organisms. In epithelial cells, E …