Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

Plant electrical signals, an early event in the plant–stimulus interaction, rapidly transmit
information generated by the stimulus to other organs, and even the whole plant, to promote …

Signaling nanodomains rely on spatial organization of proteins to allow controlled
intracellular signaling. Examples include calcium release sites of cardiomyocytes where …

The factors responsible for the regulation of regenerative calcium-induced calcium release
(CICR) during Ca 2+ spark evolution remain unclear. Cardiac ryanodine receptor (RyR) …

The ability of cells to sense and respond to physical forces has been recognized for
decades, but researchers are only beginning to appreciate the fundamental importance of …

In the heart, coupling between excitation of the surface membrane and activation of
contractile apparatus is mediated by Ca released from the sarcoplasmic reticulum (SR) …

The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

Ryanodine receptors (RyRs) are the Ca 2+ release channels in the sarcoplasmic reticulum
in striated muscle which play an important role in excitation-contraction coupling and cardiac …

Regulation of intracellular calcium is a critical component of cardiac electrophysiology and
excitation-contraction coupling. The calcium spark, the fundamental element of the …

Rationale: In cardiac dyads, junctional Ca2+ directly controls the gating of the ryanodine
receptors (RyRs), and is itself dominated by RyR-mediated Ca2+ release from the …