Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells

Y Liu, X Shen, Y Zhang, X Zheng, C Cepeda, Y Wang… - Glia, 2023 - Wiley Online Library
The mammalian brain is a complex organ comprising neurons, glia, and more than 1× 1014
synapses. Neurons are a heterogeneous group of electrically active cells, which form the …

The role of astrocytic α7 nicotinic acetylcholine receptors in Alzheimer disease

IC Fontana, A Kumar, A Nordberg - Nature Reviews Neurology, 2023 - nature.com
The ongoing search for therapeutic interventions in Alzheimer disease (AD) has highlighted
the complexity of this condition and the need for additional biomarkers, beyond amyloid-β …

Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst

X Gao, H Wei, W Ma, W Wu, W Ji, J Mao, P Yu… - Nature …, 2024 - nature.com
Electrochemical methods with tissue-implantable microelectrodes provide an excellent
platform for real-time monitoring the neurochemical dynamics in vivo due to their superior …

Neuron-astrocyte omnidirectional signaling in neurological health and disease

D Pathak, K Sriram - Frontiers in molecular neuroscience, 2023 - frontiersin.org
Astrocytes are an abundantly distributed population of glial cells in the central nervous
system (CNS) that perform myriad functions in the normal and injured/diseased brain …

Astrocytes and major depression: The purinergic avenue

YF Zhao, A Verkhratsky, Y Tang, P Illes - Neuropharmacology, 2022 - Elsevier
Major depressive disorder (MDD) is one of the most prevalent psychiatric illnesses
worldwide which impairs the social functioning of the afflicted patients. Astrocytes promote …

Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice

F Wang, W Wang, S Gu, D Qi, NA Smith… - Nature …, 2023 - nature.com
Despite extensive research on astrocytic Ca2+ in synaptic transmission, its contribution to
the modulation of sensory transmission during different brain states remains largely …

Astrocytes as master modulators of neural networks: Synaptic functions and disease‐associated dysfunction of astrocytes

JA Stogsdill, CC Harwell… - Annals of the New York …, 2023 - Wiley Online Library
Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …

Astrocytic modulation of neuronal signalling

SS Purushotham, Y Buskila - Frontiers in Network Physiology, 2023 - frontiersin.org
Neuronal signalling is a key element in neuronal communication and is essential for the
proper functioning of the CNS. Astrocytes, the most prominent glia in the brain play a key …

Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression

J Liu, JW Mo, X Wang, Z An, S Zhang, CY Zhang… - Science …, 2022 - science.org
Major depressive disorder (MDD) is a devastating mental disorder that affects up to 17% of
the population worldwide. Although brain-wide network-level abnormalities in MDD patients …

Astrocyte metabolism and signaling pathways in the CNS

Y Zhang, Y Qi, Y Gao, W Chen, T Zhou… - Frontiers in …, 2023 - frontiersin.org
Astrocytes comprise half of the cells in the central nervous system and play a critical role in
maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated …