Enzymes can be engineered at the level of their amino acid sequences to optimize key
properties such as expression, stability, substrate range, and catalytic efficiency─ or even to …

We present MoCHI, a tool to fit interpretable models using deep mutational scanning data.
MoCHI infers free energy changes, as well as interaction terms (energetic couplings) for …

A protein's genetic architecture–the set of causal rules by which its sequence produces its
functions–also determines its possible evolutionary trajectories. Prior research has …

Missense variants that change the amino acid sequences of proteins cause one-third of
human genetic diseases. Tens of millions of missense variants exist in the current human …

Cells have evolved mechanisms to distribute~ 10 billion protein molecules to subcellular
compartments where diverse proteins involved in shared functions must assemble. Here, we …

Motivated by recent deep mutational scanning (DMS) experiments, we have carried out a
diverse set of computations to better understand the distribution and contributions of …

Missense variants that change the amino acid sequences of proteins cause one third of
human genetic diseases. Tens of millions of missense variants exist in the current human …

Motivation Antibody therapeutic candidates must exhibit not only tight binding to their target
but also good developability properties, especially low risk of immunogenicity. Results In this …

Stabilizing proteins without otherwise hampering their function is a central task in protein
engineering and design. PYR1 is a plant hormone receptor that has been engineered to …

Cells have evolved mechanisms to distribute∼ 10 billion protein molecules to subcellular
compartments where diverse proteins involved in shared functions must efficiently …