Light is a particularly appealing tool for on‐demand drug delivery due to its noninvasive
nature, ease of application, and exquisite temporal and spatial control. Great progress is …

Biological signalling is regulated through a complex and tightly choreographed interplay
between cells and their extracellular matrix. The spatiotemporal control of these interactions …

Designer DNA nanodevices have attracted extensive interest for detection of specific targets
in living cells. However, it still remains a great challenge to construct DNA sensing devices …

Nanodevices have potential as intelligent sensing systems for detection of microRNAs
(miRNAs) in living cells. However, the resolution offered by “always active” nanodevices is …

It is crucial to deliver anticancer drugs to target cells with high precision and efficiency. While
nanomaterials have been shown to enhance the delivery efficiency once they reach the …

While proteolysis-targeting chimeras (PROTACs) are showing promise for targeting
previously undruggable molecules, their application has been limited by difficulties in …

Immunomodulatory therapies are becoming a paradigm-shifting treatment modality for
cancer. Despite promising clinical results, cancer immunotherapy is accompanied with off …

Despite the potential of nanodevices for intelligent drug delivery, it remains challenging to
develop controllable therapeutic devices with high spatial-temporal selectivity. Here, we …

Cell and organelle targeting of nanomedicines are two cascade processes that lead to drug
internalization and subsequent enrichment on the final target. However, it is still challenging …

The ability to remotely trigger CRISPR/Cas9 activity would enable new strategies to study
cellular events with greater precision and complexity. In this work, we have developed a …