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Research priorities for an HIV cure: international AIDS society global scientific strategy 2021
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics
A latent reservoir for HIV-1 in resting CD4+ T lymphocytes precludes cure. Mechanisms
underlying reservoir stability are unclear. Recent studies suggest an unexpected degree of …
underlying reservoir stability are unclear. Recent studies suggest an unexpected degree of …
CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART
HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART).
Identifying cellular markers expressed at the surface of these cells may lead to novel …
Identifying cellular markers expressed at the surface of these cells may lead to novel …
Defective HIV-1 proviruses are expressed and can be recognized by cytotoxic T lymphocytes, which shape the proviral landscape
Despite antiretroviral therapy, HIV-1 persists in memory CD4+ T cells, creating a barrier to
cure. The majority of HIV-1 proviruses are defective and considered clinically irrelevant …
cure. The majority of HIV-1 proviruses are defective and considered clinically irrelevant …
International AIDS Society global scientific strategy: towards an HIV cure 2016
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …
global population of more than 35 million people living with HIV, there is intense interest in …
[HTML][HTML] Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
Antiretroviral therapy fails to cure HIV-1 infection because latent proviruses persist in resting
CD4+ T cells. T cell activation reverses latency, but< 1% of proviruses are induced to …
CD4+ T cells. T cell activation reverses latency, but< 1% of proviruses are induced to …
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection
The phenotypic characterization of the cells in which HIV persists during antiretroviral
therapy (ART) remains technically challenging. We developed a simple flow cytometry …
therapy (ART) remains technically challenging. We developed a simple flow cytometry …
Elimination of HIV-1 genomes from human T-lymphoid cells by CRISPR/Cas9 gene editing
We employed an RNA-guided CRISPR/Cas9 DNA editing system to precisely remove the
entire HIV-1 genome spanning between 5′ and 3′ LTRs of integrated HIV-1 proviral DNA …
entire HIV-1 genome spanning between 5′ and 3′ LTRs of integrated HIV-1 proviral DNA …