The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1
and-2 activate two G-protein coupled receptors, ET A and ET B, with equal affinity, whereas …

At present, diabetic kidney disease affects about 15–25% of type 1 and 30–40% of type 2
diabetic patients. Several decades of extensive research has elucidated various pathways to …

Among the several theories on the pathophysiology of progressive nephropathies [1—41,
the most convincing one [1, 2] suggests that the initial reduction in nephron number …

The human endothelin-1 (ET-1) gene under the control of its natural promoter was
transferred into the germline of mice. The transgene was expressed predominantly in the …

Simple Summary In this review, we describe the basic functions of endothelin and related
molecules, including their receptors and enzymes. Furthermore, we discuss the important …

Endothelin (ET) 1 is a potent vasoactive peptide implicated in the pathogenesis of
hypertension and renal disease. The aim of the current study was to test the hypotheses that …

The rat has classically been the species of choice for pharmacological studies and disease
modeling, providing a source of high-quality physiological data on cardiovascular and renal …

Background: Diabetic nephropathy is the leading cause of end-stage renal disease in
European countries and is associated with an enhanced renal synthesis of endothelin (ET) …

Endothelin-1,(ET-1, EDN1) is an endogenous polypeptide which demonstrates dominant
vasoconstriction activity and mitogenic effect. It has positive inotropic and chronotropic …

Chronic nephropathies are associated with enhanced renal synthesis of endothelin (ET)-1.
A recent study demonstrated that an ET (A) receptor antagonist given to diabetic rats at the …