Psoriasis is an incurable cutaneous illness characterized by the presence of well-delimited
reddish plaques and silvery-white dry scales. So far, there is a limited understanding of its …

Organophosphates (OPs) used as potent insecticides for malaria vector control, covalently
phosphorylate the catalytic serine residue of Anopheles gambiae AChE (Ag AChE) in a …

Please cite this paper as: Upregulation of cathepsin S in psoriatic keratinocytes.
Experimental Dermatology 2010; 19: e80–e88. Abstract: Cathepsin S (CATS) is a cysteine …

We participated in the Cathepsin S (CatS) sub-challenge of the Drug Design Data Resource
(D3R) Grand Challenge 3 (GC3) in 2017 to blindly predict the binding poses of 24 CatS …

Cathepsin S (CatS) is one of the cysteinyl cathepsins widely studied for its clinical
significance and found to be a promising therapeutic target for several diseases; to name a …

We recently reported an integrated fragment-based optimization strategy called DOTS
(Diversity Oriented Target-focused Synthesis) that combines automated virtual screening …

Background Redox cycling compounds have been reported to cause false positive inhibition
of proteases in drug discovery studies. This kind of false positives can lead to unusually high …

Safe and effective algaecides are needed to control agriculturally and environmentally
significant algal species. Four series (6, 10, 17, and 21) of 29 novel 4-aminopyrimidine …

Cathepsin S has been demonstrated to play a crucial role in the remodeling of extracellular
matrix proteins such as elastin and collagen, which in turn contribute to the structural …

The ubiquitin–proteasome pathway plays a pivotal role in the regulation of cellular protein
processing and degradation. Proteasome inhibitors (PIs) have enormous potential to treat …