[HTML][HTML] Enterovirus A71 antivirals: past, present, and future

J Wang, Y Hu, M Zheng - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Abstract Enterovirus A71 (EV-A71) is a significant human pathogen, especially in children.
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …

A systems approach to infectious disease

M Eckhardt, JF Hultquist, RM Kaake… - Nature Reviews …, 2020 - nature.com
Ongoing social, political and ecological changes in the 21st century have placed more
people at risk of life-threatening acute and chronic infections than ever before. The …

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection

CM Richards, S Jabs, W Qiao, LD Varanese… - Science, 2022 - science.org
Lysosomes are key degradative compartments of the cell. Transport to lysosomes relies on
GlcNAc-1-phosphotransferase–mediated tagging of soluble enzymes with mannose 6 …

Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets

KM Haas, MJ McGregor, M Bouhaddou… - Nature …, 2023 - nature.com
Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of
antiviral therapies. Understanding host proteins essential for IAV infection can identify …

hu. MAP 2.0: integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies

K Drew, JB Wallingford, EM Marcotte - Molecular systems biology, 2021 - embopress.org
A general principle of biology is the self‐assembly of proteins into functional complexes.
Characterizing their composition is, therefore, required for our understanding of cellular …

Acyl-coenzyme a synthetase long-chain family member 4 is involved in viral replication organelle formation and facilitates virus replication via ferroptosis

YA Kung, HJ Chiang, ML Li, YN Gong, HP Chiu… - Mbio, 2022 - journals.asm.org
Enterovirus infections can cause severe complications, such as poliomyelitis, encephalitis,
myocarditis, meningitis, neurological pulmonary edema, and even death. Here, we used …

Enterovirus D68 antivirals: past, present, and future

Y Hu, R Musharrafieh, M Zheng… - ACS infectious diseases, 2020 - ACS Publications
Enterovirus D68 (EV-D68) is an RNA virus that causes respiratory illnesses mainly in
children. In severe cases, it can lead to neurological complications such as acute flaccid …

[PDF][PDF] A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing

MJ O'Meara, JZ Guo, DL Swaney, TA Tummino… - BioRxiv, 2020 - biorxiv.org
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19
respiratory disease, has infected over 290,000 people since the end of 2019, killed over …

The EV71 2A protease occupies the central cleft of SETD3 and disrupts SETD3-actin interaction

X Gao, B Wang, K Zhu, L Wang, B Qin, K Shang… - Nature …, 2024 - nature.com
SETD3 is an essential host factor for the replication of a variety of enteroviruses that
specifically interacts with viral protease 2A. However, the interaction between SETD3 and …