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[HTML][HTML] Enterovirus A71 antivirals: past, present, and future
Abstract Enterovirus A71 (EV-A71) is a significant human pathogen, especially in children.
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …
A systems approach to infectious disease
M Eckhardt, JF Hultquist, RM Kaake… - Nature Reviews …, 2020 - nature.com
Ongoing social, political and ecological changes in the 21st century have placed more
people at risk of life-threatening acute and chronic infections than ever before. The …
people at risk of life-threatening acute and chronic infections than ever before. The …
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection
Lysosomes are key degradative compartments of the cell. Transport to lysosomes relies on
GlcNAc-1-phosphotransferase–mediated tagging of soluble enzymes with mannose 6 …
GlcNAc-1-phosphotransferase–mediated tagging of soluble enzymes with mannose 6 …
Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets
KM Haas, MJ McGregor, M Bouhaddou… - Nature …, 2023 - nature.com
Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of
antiviral therapies. Understanding host proteins essential for IAV infection can identify …
antiviral therapies. Understanding host proteins essential for IAV infection can identify …
hu. MAP 2.0: integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies
A general principle of biology is the self‐assembly of proteins into functional complexes.
Characterizing their composition is, therefore, required for our understanding of cellular …
Characterizing their composition is, therefore, required for our understanding of cellular …
Acyl-coenzyme a synthetase long-chain family member 4 is involved in viral replication organelle formation and facilitates virus replication via ferroptosis
Enterovirus infections can cause severe complications, such as poliomyelitis, encephalitis,
myocarditis, meningitis, neurological pulmonary edema, and even death. Here, we used …
myocarditis, meningitis, neurological pulmonary edema, and even death. Here, we used …
Enterovirus D68 antivirals: past, present, and future
Y Hu, R Musharrafieh, M Zheng… - ACS infectious diseases, 2020 - ACS Publications
Enterovirus D68 (EV-D68) is an RNA virus that causes respiratory illnesses mainly in
children. In severe cases, it can lead to neurological complications such as acute flaccid …
children. In severe cases, it can lead to neurological complications such as acute flaccid …
[PDF][PDF] A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19
respiratory disease, has infected over 290,000 people since the end of 2019, killed over …
respiratory disease, has infected over 290,000 people since the end of 2019, killed over …
The EV71 2A protease occupies the central cleft of SETD3 and disrupts SETD3-actin interaction
X Gao, B Wang, K Zhu, L Wang, B Qin, K Shang… - Nature …, 2024 - nature.com
SETD3 is an essential host factor for the replication of a variety of enteroviruses that
specifically interacts with viral protease 2A. However, the interaction between SETD3 and …
specifically interacts with viral protease 2A. However, the interaction between SETD3 and …