Updating Phospholipase A2 Biology
M Murakami, H Sato, Y Taketomi - Biomolecules, 2020 - mdpi.com
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …
are subdivided into several distinct families on a structural and biochemical basis. In …
Anti-inflammatory therapies for atherosclerosis
The view of atherosclerosis as an inflammatory disease has emerged from observations of
immune activation and inflammatory signalling in human atherosclerotic lesions, from the …
immune activation and inflammatory signalling in human atherosclerotic lesions, from the …
Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity
T cells are often absent from human cancer tissues during both spontaneously induced
immunity and therapeutic immunotherapy, even in the presence of a functional T cell …
immunity and therapeutic immunotherapy, even in the presence of a functional T cell …
Molecular biology of atherosclerosis
PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial
Importance Secretory phospholipase A 2 (sPLA 2) generates bioactive phospholipid
products implicated in atherosclerosis. The sPLA 2 inhibitor varespladib has favorable …
products implicated in atherosclerosis. The sPLA 2 inhibitor varespladib has favorable …
[HTML][HTML] A twist of FATe: Lipid droplets and inflammatory lipid mediators
Lipid droplets are fat storage organelles present in most eukaryotic cells. They consist of a
neutral lipid core containing mostly triglycerides and sterol esters and covered by a …
neutral lipid core containing mostly triglycerides and sterol esters and covered by a …
Selectivity of phospholipid hydrolysis by phospholipase A2 enzymes in activated cells leading to polyunsaturated fatty acid mobilization
Phospholipase A 2 s are enzymes that hydrolyze the fatty acid at the sn-2 position of the
glycerol backbone of membrane glycerophospholipids. Given the asymmetric distribution of …
glycerol backbone of membrane glycerophospholipids. Given the asymmetric distribution of …
DNA methylation map of human atherosclerosis
Background—Epigenetic alterations may contribute to the development of atherosclerosis.
In particular, DNA methylation, a reversible and highly regulated DNA modification, could …
In particular, DNA methylation, a reversible and highly regulated DNA modification, could …
A new era of secreted phospholipase A2
M Murakami, H Sato, Y Miki, K Yamamoto… - Journal of lipid …, 2015 - ASBMB
Among more than 30 members of the phospholipase A 2 (PLA 2) superfamily, secreted PLA
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …
Targeting the Immune System in Atherosclerosis: JACC State-of-the-Art Review
Atherosclerosis has long been known as an inflammatory disease. However, whether
targeting inflammation improves outcomes was unproven until the recent results of CANTOS …
targeting inflammation improves outcomes was unproven until the recent results of CANTOS …