Endocytosis in cancer and cancer therapy
Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
T-cell exhaustion in chronic infections: reversing the state of exhaustion and reinvigorating optimal protective immune responses
T-cell exhaustion is a phenomenon of dysfunction or physical elimination of antigen-specific
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
Chimeric antigen receptor designed to prevent ubiquitination and downregulation showed durable antitumor efficacy
W Li, S Qiu, J Chen, S Jiang, W Chen, J Jiang, F Wang… - Immunity, 2020 - cell.com
Clinical evidence suggests that poor persistence of chimeric antigen receptor-T cells (CAR-
T) in patients limits therapeutic efficacy. Here, we designed a CAR with recyclable capability …
T) in patients limits therapeutic efficacy. Here, we designed a CAR with recyclable capability …
Spoiled for choice: diverse endocytic pathways function at the cell surface
Endocytosis has long been identified as a key cellular process involved in bringing in
nutrients, in clearing cellular debris in tissue, in the regulation of signaling, and in …
nutrients, in clearing cellular debris in tissue, in the regulation of signaling, and in …
Mechanisms and functions of endocytosis in T cells
Once thought of primarily as a means to neutralize pathogens or to facilitate feeding,
endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among …
endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among …
[HTML][HTML] Clathrin-independent endocytosis, retrograde trafficking, and cell polarity
Several mechanisms allow for cargo internalization into cells within membrane-bound
endocytic carriers. How these internalization processes couple to specific pathways of …
endocytic carriers. How these internalization processes couple to specific pathways of …
[HTML][HTML] Flotillins: At the Intersection of Protein S-Palmitoylation and Lipid-Mediated Signaling
K Kwiatkowska, OV Matveichuk, J Fronk… - International Journal of …, 2020 - mdpi.com
Flotillin-1 and flotillin-2 are ubiquitously expressed, membrane-associated proteins involved
in multifarious cellular events from cell signaling, endocytosis, and protein trafficking to gene …
in multifarious cellular events from cell signaling, endocytosis, and protein trafficking to gene …
Membrane heterogeneity controls cellular endocytic trafficking
Endocytic trafficking relies on highly localized events in cell membranes. Endocytosis
involves the gathering of protein (cargo/receptor) at distinct plasma membrane locations …
involves the gathering of protein (cargo/receptor) at distinct plasma membrane locations …
Plasmacytoid dendritic cells and infected cells form an interferogenic synapse required for antiviral responses
Summary Type I interferon (IFN-I) is critical for antiviral defense, and plasmacytoid dendritic
cells (pDCs) are a predominant source of IFN-I during virus infection. pDC-mediated antiviral …
cells (pDCs) are a predominant source of IFN-I during virus infection. pDC-mediated antiviral …
Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse
Ligation of T cell receptor (TCR) to peptide–MHC (pMHC) complexes initiates signaling
leading to T cell activation and TCR ubiquitination. Ubiquitinated TCR is then either …
leading to T cell activation and TCR ubiquitination. Ubiquitinated TCR is then either …