Antisense technology is beginning to deliver on the broad promise of the technology. Ten
RNA-targeted drugs including eight single-strand antisense drugs (ASOs) and two double …

Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

Functional nucleic acid (NA)-based drugs have a broad range of applications since they
allow the alteration and control of gene/protein expression patterns in cells. In principle …

Aptamers are short, single-stranded oligonucleotides that bind to specific target molecules.
The shape-forming feature of single-stranded oligonucleotides provides high affinity and …

Antisense oligonucleotides (ASOs) modified with phosphorothioate (PS) linkages and
different 2′ modifications can be used either as drugs (eg, to treat homozygous familial …

Aptamers are single-stranded DNA or RNA molecules capable of tightly binding to specific
targets. These functional nucleic acids are obtained by an in vitro Darwinian evolution …

Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and
are commonly produced by systematic evolution of ligands by exponential enrichment …

Nucleic acid aptamers are ssDNA or ssRNA fragments that specifically recognize targets.
However, the pharmacodynamic properties of natural aptamers consisting of 4 naturally …

Efficient nuclear DNA damage and release is highly recommended to improve the
photodynamic immunotherapy by eliciting innate immune response yet remains challenging …

Background AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-
quadruplex structures. It was identified based on its cancer-selective antiproliferative activity …