Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine

C Cayrol, JP Girard - Cytokine, 2022 - Elsevier
Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …

IL-33, an alarmin of the IL-1 family involved in allergic and non allergic inflammation: focus on the mechanisms of regulation of its activity

C Cayrol - Cells, 2021 - mdpi.com
Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) family that is expressed in the
nuclei of endothelial and epithelial cells of barrier tissues, among others. It functions as an …

The immunological impact of IL-1 family cytokines on the epidermal barrier

T Macleod, A Berekmeri, C Bridgewood… - Frontiers in …, 2021 - frontiersin.org
The skin barrier would not function without IL-1 family members, but their physiological role
in the immunological aspects of skin barrier function are often overlooked. This review …

Intestinal immune responses to commensal and pathogenic protozoa

A Sardinha-Silva, EVC Alves-Ferreira… - Frontiers in …, 2022 - frontiersin.org
The physical barrier of the intestine and associated mucosal immunity maintains a delicate
homeostatic balance between the host and the external environment by regulating immune …

Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

EM Frickel, CA Hunter - Journal of Experimental Medicine, 2021 - rupress.org
The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

The role of IFN-γ-mediated host immune responses in monitoring and the elimination of Toxoplasma gondii infection

F Ihara, M Yamamoto - International Immunology, 2024 - academic.oup.com
Toxoplasma gondii is a pathogenic protozoan parasite of the Apicomplexa family that affects
approximately 30% of the world's population. Symptoms are usually mild in …

IL-33 in rheumatic diseases

Y Dong, J Zhong, L Dong - Frontiers in medicine, 2021 - frontiersin.org
Interleukin-33 (IL-33) is a nuclear factor mainly expressed in barrier epithelium, endothelial
cells, and fibroblast reticular cells. Some inflammatory cells also express IL-33 under certain …

Immune system roles in pathogenesis, prognosis, control, and treatment of Toxoplasma gondii infection

MM Jafari, ZA Tabrizi, MS Dayer… - International …, 2023 - Elsevier
Toxoplasma gondii is the protozoan causative agent of toxoplasmosis in humans and warm-
blooded animals. Recent studies have illustrated that the immune system plays a pivotal role …

IL-33/ST2 signaling promotes constitutive and inductive PD-L1 expression and immune escape in oral squamous cell carcinoma

M Zhao, Y He, N Zhu, Y Song, Q Hu, Z Wang… - British Journal of …, 2023 - nature.com
Background Loss-of-function of PD-L1 induces therapy resistance of anti-PD-1/L1 therapy,
and the complex regulatory mechanisms are not completely understood. We previously …

ILC1-derived IFN-γ regulates macrophage activation in colon cancer

Y Zhang, S Ma, T Li, Y Tian, H Zhou, H Wang, L Huang - Biology direct, 2023 - Springer
Abstract Background Tumor-associated macrophages (TAMs) are an important subset of
innate immune cells in the tumor microenvironment, and they are pivotal regulators of tumor …