Pain regulation by non-neuronal cells and inflammation
Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis,
nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a …
nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a …
Nociceptor sensory neuron–immune interactions in pain and inflammation
Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …
Acute inflammatory response via neutrophil activation protects against the development of chronic pain
The transition from acute to chronic pain is critically important but not well understood. Here,
we investigated the pathophysiological mechanisms underlying the transition from acute to …
we investigated the pathophysiological mechanisms underlying the transition from acute to …
[HTML][HTML] Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury
Primary somatosensory neurons are specialized to transmit specific types of sensory
information through differences in cell size, myelination, and the expression of distinct …
information through differences in cell size, myelination, and the expression of distinct …
The microbiome and host behavior
The microbiota is increasingly recognized for its ability to influence the development and
function of the nervous system and several complex host behaviors. In this review, we …
function of the nervous system and several complex host behaviors. In this review, we …
Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation
This study shows that the supramolecular arrangement of proteins in nanoparticle structures
predicts nanoparticle accumulation in neutrophils in acute lung inflammation (ALI). We …
predicts nanoparticle accumulation in neutrophils in acute lung inflammation (ALI). We …
Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia
Lung-innervating nociceptor sensory neurons detect noxious or harmful stimuli and
consequently protect organisms by mediating coughing, pain, and bronchoconstriction …
consequently protect organisms by mediating coughing, pain, and bronchoconstriction …
Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain
PCT Tang, JYF Chung, J Liao, MKK Chan… - Science …, 2022 - science.org
Tumor innervation is a common phenomenon with unknown mechanism. Here, we
discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de …
discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de …
Biomimetic Hydroxyapatite Nanorods Promote Bone Regeneration via Accelerating Osteogenesis of BMSCs through T Cell-Derived IL-22
F Yu, R Lian, L Liu, T Liu, C Bi, K Hong, S Zhang… - Acs Nano, 2022 - ACS Publications
Manipulations of morphological properties of nanobiomaterials have been demonstrated to
modulate the outcome of osteoimmunomodulation and eventually osteogenesis through …
modulate the outcome of osteoimmunomodulation and eventually osteogenesis through …
The NLRP3 inflammasome: an emerging therapeutic target for chronic pain
R Chen, C Yin, J Fang, B Liu - Journal of neuroinflammation, 2021 - Springer
Chronic pain affects the life quality of the suffering patients and posts heavy problems to the
health care system. Conventional medications are usually insufficient for chronic pain …
health care system. Conventional medications are usually insufficient for chronic pain …