Wet granulation is a key step in the pharmaceutical manufacturing of solid-dosage forms.
Wet granulation is used in pharmaceutical production to enhance formulation qualities such …

Process simulation using mathematical modeling tools is becoming more common in the
pharmaceutical industry. A mechanistic model is a mathematical modeling tool that can …

Powder-layering is an essential process of selective laser melting (SLM), but the underlying
mechanisms of powder movement and packing at particle scale is unclear. Based on …

High shear wet granulation (HSWG) is considered a complicated and multivariate
pharmaceutical process that is influenced by a large number of variables derived from …

The manufacturing of pharmaceutical dosage forms, which has traditionally been a batch-
wise process, is now also transformed into a series of continuous operations. Some …

Multiphase chemical reactors with characteristic multiscale structures are intrinsically
discrete at the elemental scale. However, due to the lack of multiscale models and the …

Numerical simulation of wet granulation in a continuous granulator is carried out using
Discrete Element Method (DEM) to discover the possibility of formation of seeded granules …

Conducting a numerical simulation for cohesive granular mixtures that is well comparable
with experiments has always been a challenge. In this study, a systematic methodology is …

Granulation is an important process in iron ore sintering to increase particle size for better
permeability. In this study, the granulation of mixed iron ore, coke, and flux in a rotating drum …

Twin-screw granulation is a promising continuous manufacturing technique for producing
granules with tailored properties. This study investigates the impact of screw configuration …