Parkinson's disease is a common movement disorder seen in neurological practice, but the
diagnosis and management is challenging. The diagnosis is clinical and sometimes difficult …

Parkinson disease is the second-most common neurodegenerative disorder that affects 2–
3% of the population≥ 65 years of age. Neuronal loss in the substantia nigra, which causes …

Abstract Dynamic Causal Modelling (DCM) is the predominant method for inferring effective
connectivity from neuroimaging data. In the 15 years since its introduction, the neural …

Parkinson disease (PD) is characterized by heterogeneous motor and non-motor symptoms,
resulting from neurodegeneration involving various parts of the central nervous system …

Hypometabolism, characterized by decreased brain glucose consumption, is a common
feature of many neurodegenerative diseases. Initial hypometabolic brain state, created by …

Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …

Tremor is one of the primary motor symptoms of Parkinson's disease (PD), and it is
characterized by a highly phenomenological heterogeneity. Clinical and experimental …

This review is part of the series on the clinical neurophysiology of movement disorders. It
focuses on Parkinson's disease and parkinsonism. The topics covered include the …

Traditionally, the basal ganglia have been considered the main brain region implicated in
Parkinson's disease. This single area perspective gives a restricted clinical picture and limits …

Parkinson's resting tremor is related to altered cerebral activity in the basal ganglia and the
cerebello-thalamo-cortical circuit. Although Parkinson's disease is characterized by …