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Synergistic enhancement: Exploring the potential of piperine in cancer therapeutics through chemosensitization and combination therapies
Despite significant advancements in chemotherapy, effective treatments for advanced
cancer stages remain largely elusive due to chemoresistance. Resistance to anticancer …
cancer stages remain largely elusive due to chemoresistance. Resistance to anticancer …
Molecular mechanisms of Hippo pathway in tumorigenesis: therapeutic implications
The Hippo signaling pathway is a pivotal regulator of tissue homeostasis, organ size, and
cell proliferation. Its dysregulation is profoundly implicated in various forms of cancer …
cell proliferation. Its dysregulation is profoundly implicated in various forms of cancer …
LPA released from dying cancer cells after chemotherapy inactivates Hippo signaling and promotes pancreatic cancer cell repopulation
Y Liu, J Ding, S Li, A Jiang, Z Chen, M Quan - Cellular Oncology, 2025 - Springer
Abstract Purpose The Hippo pathway in the tumorigenesis and progression of PDAC, with
lysophosphatidic acid (LPA) regulating the Hippo pathway to facilitate cancer progression …
lysophosphatidic acid (LPA) regulating the Hippo pathway to facilitate cancer progression …
Transient activation of YAP/TAZ confers resistance to morusin-induced apoptosis
H Lee, SW Cho, HS Cha, K Tae, CY Choi - BMC Molecular and Cell …, 2025 - Springer
Abstract Background The Hippo signaling pathway involves a kinase cascade that controls
phosphorylation of the effector proteins YAP and TAZ, leading to regulation of cell growth …
phosphorylation of the effector proteins YAP and TAZ, leading to regulation of cell growth …
YAP1 Overexpression Enhances the Aerobic Glycolysis Process via Suppression of EGLN2 in Pancreatic Ductal Adenocarcinoma
P Hu, R Dou, Z Qi, G Liu, Y Su - The Journal of Gene Medicine, 2024 - Wiley Online Library
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive
diseases and has remarkably high mortality rates. In recent years, altered metabolism has …
diseases and has remarkably high mortality rates. In recent years, altered metabolism has …
LPA released from dying cancer cells after chemotherapy inactivates Hippo signaling and promotes pancreatic cancer cell repopulation
L Yuzhi, D Jie, L Shumin, A Jiang, Z Chen, M Quan - 2024 - researchsquare.com
Gemcitabine-based chemotherapy remains the cornerstone of comprehensive treatment for
pancreatic ductal adenocarcinoma (PDAC). A significant bottleneck in tumor therapeutic …
pancreatic ductal adenocarcinoma (PDAC). A significant bottleneck in tumor therapeutic …