Cervical cancer is one of the foremost common cancers in women. Human papillomavirus
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …

Apolipoprotein B editing complex 3 family members are cytidine deaminases that play
important roles in intrinsic responses to infection by retroviruses and have been implicated …

Understanding the prevailing mutational mechanisms responsible for human genome
structural variation requires uniformity in the discovery of allelic variants and precision in …

Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes
are capable of inhibiting a wide range of endogenous and exogenous viruses using …

Restriction factors are natural cellular proteins that defend individual cells from viral
infection. These factors include the APOBEC3 family of DNA cytidine deaminases, which …

Background Genome-wide association studies (GWASs) have identified multiple genetic
susceptibility loci for breast cancer. However, these loci explain only a small fraction of the …

INTRODUCTION Characterizing genetic variants underlying local adaptations in human
populations is one of the central goals of evolutionary research. Most studies have focused …

Twenty-five years after the discovery of HIV as the cause of AIDS there is still no effective
vaccine and no cure for this disease. HIV susceptibility shows a substantial degree of …

The APOBEC family of proteins comprises deaminase enzymes that edit DNA and/or RNA
sequences. The APOBEC3 subgroup plays an important role on the innate immune system …

The development of a safe, effective and globally affordable HIV vaccine offers the best
hope for the future control of the HIV-1 pandemic. Since 1987, scores of candidate HIV-1 …