Classification and evolution of type II CRISPR-Cas systems
The CRISPR-Cas systems of archaeal and bacterial adaptive immunity are classified into
three types that differ by the repertoires of CRISPR-associated (cas) genes, the organization …
three types that differ by the repertoires of CRISPR-associated (cas) genes, the organization …
Comparative genomics of defense systems in archaea and bacteria
Our knowledge of prokaryotic defense systems has vastly expanded as the result of
comparative genomic analysis, followed by experimental validation. This expansion is both …
comparative genomic analysis, followed by experimental validation. This expansion is both …
Protospacer recognition motifs: mixed identities and functional diversity
Protospacer adjacent motifs (PAMs) were originally characterized for CRISPR-Cas systems
that were classified on the basis of their CRISPR repeat sequences. A few short 2–5 bp …
that were classified on the basis of their CRISPR repeat sequences. A few short 2–5 bp …
Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis
CRISPR interference confers adaptive, sequence-based immunity against viruses and
plasmids and is specified by CRISPR RNAs (crRNAs) that are transcribed and processed …
plasmids and is specified by CRISPR RNAs (crRNAs) that are transcribed and processed …
The CRISPRs, they are a-changin': how prokaryotes generate adaptive immunity
All organisms need to continuously adapt to changes in their environment. Through
horizontal gene transfer, bacteria and archaea can rapidly acquire new traits that may …
horizontal gene transfer, bacteria and archaea can rapidly acquire new traits that may …
Harnessing Type I and Type III CRISPR-Cas systems for genome editing
Y Li, S Pan, Y Zhang, M Ren, M Feng… - Nucleic acids …, 2016 - academic.oup.com
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-
associated) systems are widespread in archaea and bacteria, and research on their …
associated) systems are widespread in archaea and bacteria, and research on their …
[HTML][HTML] Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus
The CRISPR-Cas system is a prokaryotic host defense system against genetic elements.
The Type III-B CRISPR-Cas system of the bacterium Thermus thermophilus, the TtCmr …
The Type III-B CRISPR-Cas system of the bacterium Thermus thermophilus, the TtCmr …
A novel interference mechanism by a type IIIB CRISPR‐Cmr module in Sulfolobus
Recent studies on CRISPR‐based adaptive immune systems have revealed extensive
structural and functional diversity of the interference complexes which often coexist …
structural and functional diversity of the interference complexes which often coexist …
Function and regulation of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated (Cas) systems
Phages are the most abundant biological entities on earth and pose a constant challenge to
their bacterial hosts. Thus, bacteria have evolved numerous 'innate'mechanisms of defense …
their bacterial hosts. Thus, bacteria have evolved numerous 'innate'mechanisms of defense …
Not all predicted CRISPR–Cas systems are equal: isolated cas genes and classes of CRISPR like elements
Abstract Background The CRISPR–Cas systems in prokaryotes are RNA-guided immune
systems that target and deactivate foreign nucleic acids. A typical CRISPR–Cas system …
systems that target and deactivate foreign nucleic acids. A typical CRISPR–Cas system …