The current neurosurgical goal for patients with malignant gliomas is maximal safe resection
of the contrast-enhancing tumor. However, a complete resection of the contrast-enhancing …

Background Fluorescence-guided surgery (FGS) is a technique used to enhance
visualization of tumor margins in order to increase the extent of tumor resection in glioma …

The most widely used fluorophore in glioma-resection surgery, 5-aminolevulinic acid (5-
ALA), is thought to cause the selective accumulation of fluorescent protoporphyrin IX (PpIX) …

Background We performed a systematic review and meta-analysis to address the (added)
value of intraoperative 5-aminolevulinic acid (5-ALA)-guided resection of high-grade …

Importance High-grade gliomas (HGG) are the most aggressive and common malignant
brain tumors in adults. They have a dismally fatal prognosis. Even if gross total resection of …

High-grade gliomas are still characterized by a poor prognosis, despite recent advances in
surgical treatment. Chemotherapy is currently practiced after surgery, but its efficacy is …

Objective Fluorescence guidance has a demonstrated potential in maximizing the extent of
high-grade glioma resection. Different fluorophores (fluorescent biomarkers), including 5 …

Biomedical optics is a broadly interdisciplinary field at the interface of optical engineering,
biophysics, computer science, medicine, biology, and chemistry, hel** us understand light …

Background: Glioblastoma multiforme (GBM) is one of the most deadly cancers in humans.
Despite recent advances in anti-cancer therapies, most patients with GBM die from local …

OBJECTIVE Glioblastoma (GBM) is the most common and aggressive malignant primary
brain tumor, and resection is a key part of the standard of care. In fluorescence-guided …