Underpinning IL-6 biology and emphasizing selective JAK blockade as the potential alternate therapeutic intervention for rheumatoid arthritis

S Srivastava, M Rasool - Life Sciences, 2022 - Elsevier
Abstract Interleukin 6 (IL-6), a pleiotropic inflammatory cytokine, is produced transiently due
to tissue damage and infections. Nonetheless, IL-6 contributes to the host regenerative …

Inhibitory effect of food-functioned phytochemicals on dysregulated inflammatory pathways triggered by SARS-CoV-2: a mechanistic review

I Jantan, NA Norahmad, Yuandani… - Critical Reviews in …, 2024 - Taylor & Francis
Inflammatory cascades of the dysregulated inflammatory pathways in COVID-19 can cause
excessive production of pro-inflammatory cytokines and chemokines leading to cytokine …

[HTML][HTML] Acridones as promising drug candidates against Oropouche virus

MV Saivish, G de Lima Menezes, RA da Silva… - Current research in …, 2024 - Elsevier
Oropouche virus (OROV) is an emerging vector-borne arbovirus found in South America that
causes Oropouche fever, a febrile infection similar to dengue fever. It has a high epidemic …

Exploring the anti-inflammatory potential of the polyphenolic compounds in Moringa oleifera leaf: in silico molecular docking

NM Hamdy - Egyptian Journal of Basic and Applied Sciences, 2024 - Taylor & Francis
ABSTRACT A recent study conducted an in silico model to investigate the potential of
Moringa oleifera's ethanolic leaf extract as a natural anti-inflammatory agent. The HPLC …

[HTML][HTML] Humulus lupus extract rich in xanthohumol improves the clinical course in critically ill COVID-19 patients

W Dabrowski, M Gagos, D Siwicka-Gieroba… - Biomedicine & …, 2023 - Elsevier
Background The systemic inflammatory response following severe COVID-19 is associated
with poor outcomes. Several anti-inflammatory medications have been studied in COVID-19 …

The inhibitory potential of chemical constituents of Ficus carica targeting interleukin‐6 (IL‐6) mediated inflammation

HUH Mansoor, A Ahmed… - Cell Biochemistry and …, 2023 - Wiley Online Library
Inflammation is an innate reaction of the body of an individual when subjected to the noxious
factors repeatedly. Pharmacological approaches focused at disrupting cytokine signaling …

[HTML][HTML] An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Plectranthus ornatus Codd. In Vitro and In Silico

P Sitarek, T Kowalczyk, E Synowiec… - Cells, 2022 - mdpi.com
Plectranthus ornatus Codd, the genus Plectranthus of the Lamiaceae family, has been used
as traditional medicine in Africa, India and Australia. Pharmacological studies show the use …

[HTML][HTML] The search for an antiviral lead molecule to combat the neglected emerging Oropouche virus

R dos Santos Peinado, MV Saivish… - Current research in …, 2024 - Elsevier
Oropouche virus (OROV) is a member of the Peribunyaviridae family and the causative
agent of a dengue-like febrile illness transmitted by mosquitoes. Although mild symptoms …

[HTML][HTML] Potential targets of phytochemical immunomodulatory therapy in periodontitis immunopathogenesis: A narrative review

A Sarasati, AL Jonarta - The Saudi Dental Journal, 2023 - Elsevier
Introduction Periodontitis is one of the most prevalent diseases occurring worldwide, and is
caused by an imbalance of host immunological defenses and microbiome profile which …

In silico exploration of phytochemicals as inhibitors for acute myeloid leukemia by targeting LIN28A gene: A cheminformatics study

A Hassan, SE Hassanein, EA Elabsawy - Computers in Biology and …, 2024 - Elsevier
Background Recent discoveries have illustrated that Lin28A is an oncogene in various
cancers, particularly acute myeloid leukemia (AML). The upregulation of Lin28A can actively …