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Perioperative neurocognitive disorder: state of the preclinical science
The purpose of this white paper is to provide a succinct summary of the different
experimental approaches that have been used in preclinical post-operative cognitive …
experimental approaches that have been used in preclinical post-operative cognitive …
[HTML][HTML] Sample size, power and effect size revisited: simplified and practical approaches in pre-clinical, clinical and laboratory studies
Sažetak Calculating the sample size in scientific studies is one of the critical issues as
regards the scientific contribution of the study. The sample size critically affects the …
regards the scientific contribution of the study. The sample size critically affects the …
[HTML][HTML] Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0
NP Du Sert, A Ahluwalia, S Alam, MT Avey… - PLoS …, 2020 - journals.plos.org
Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …
accurate reporting is vital to this process; it allows readers to assess the reliability of the …
Planning preclinical confirmatory multicenter trials to strengthen translation from basic to clinical research–a multi-stakeholder workshop report
NI Drude, L Martinez-Gamboa, M Danziger… - Translational Medicine …, 2022 - Springer
Clinical translation from bench to bedside often remains challenging even despite promising
preclinical evidence. Among many drivers like biological complexity or poorly understood …
preclinical evidence. Among many drivers like biological complexity or poorly understood …
Low doses of psilocybin and ketamine enhance motivation and attention in poor performing rats: evidence for an antidepressant property
GA Higgins, NK Carroll, M Brown… - Frontiers in …, 2021 - frontiersin.org
Long term benefits following short-term administration of high psychedelic doses of
serotonergic and dissociative hallucinogens, typified by psilocybin and ketamine …
serotonergic and dissociative hallucinogens, typified by psilocybin and ketamine …
Wilms tumor 1b expression defines a pro-regenerative macrophage subtype and is required for organ regeneration in the zebrafish
A Sanz-Morejon, AB Garcia-Redondo, H Reuter… - Cell reports, 2019 - cell.com
Organ regeneration is preceded by the recruitment of innate immune cells, which play an
active role during repair and regrowth. Here, we studied macrophage subtypes during organ …
active role during repair and regrowth. Here, we studied macrophage subtypes during organ …
The problem with unadjusted multiple and sequential statistical testing
C Albers - Nature Communications, 2019 - nature.com
In research studies, the need for additional samples to obtain sufficient statistical power has
often to be balanced with the experimental costs. One approach to this end is to sequentially …
often to be balanced with the experimental costs. One approach to this end is to sequentially …
Experimental replications in animal trials
F Frommlet, G Heinze - Laboratory animals, 2021 - journals.sagepub.com
The recent discussion on the reproducibility of scientific results is particularly relevant for
preclinical research with animal models. Within certain areas of preclinical research, there …
preclinical research with animal models. Within certain areas of preclinical research, there …
Effect size, sample size and power of forced swim test assays in mice: Guidelines for investigators to optimize reproducibility
NR Smalheiser, EE Graetz, Z Yu, J Wang - PloS one, 2021 - journals.plos.org
A recent flood of publications has documented serious problems in scientific reproducibility,
power, and reporting of biomedical articles, yet scientists persist in their usual practices …
power, and reporting of biomedical articles, yet scientists persist in their usual practices …
Characterization of amphetamine, methylphenidate, nicotine, and atomoxetine on measures of attention, impulsive action, and motivation in the rat: implications for …
GA Higgins, LB Silenieks, C MacMillan… - Frontiers in …, 2020 - frontiersin.org
Amphetamine (AMP), methylphenidate (MPH), and atomoxetine (ATX) are approved
treatments for ADHD, and together with nicotine (NIC), represent pharmacological agents …
treatments for ADHD, and together with nicotine (NIC), represent pharmacological agents …