The suprachiasmatic nucleus (SCN) of the hypothalamus is remarkable. Despite numbering
only about 10,000 neurons on each side of the third ventricle, the SCN is our principal …

This review explores the interface between circadian timekee** and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …

It has been 50 years since the suprachiasmatic nucleus (SCN) was first identified as the
central circadian clock and 25 years since the last overview of developments in the field was …

A substantial body of research now implicates the circadian clock in the regulation of an
array of diverse biological processes including glial function, metabolism, peripheral …

Circadian clocks sustain daily oscillations in gene expression, physiology, and behavior,
relying on transcription–translation feedback loops of clock genes for rhythm generation …

The suprachiasmatic nucleus (SCN) is the master circadian clock of mammals, generating
and transmitting an internal representation of environmental time that is produced by the cell …

Sleep is a vital and evolutionarily conserved process, critical to daily functioning and
homeostatic balance. Losing sleep is inherently stressful and leads to numerous detrimental …

Background An important goal of contemporary neuroscience research is to define the
neural circuits and synaptic interactions that mediate behavior. In both mammals and …

In mammals, circadian rhythms, such as sleep/wake cycles, are regulated by the central
circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. The …

Mammalian physiology and cellular function are subject to significant oscillations over the
course of every 24-hour day. It is likely that these daily rhythms will affect function as well as …