The beneficial or deleterious effects of nanomedicines emerge from their complex
interactions with intracellular pathways and their subcellular fate. Moreover, the dynamic …

The plasma membrane of eukaryotic cells is not a simple sheet of lipids and proteins but is
differentiated into subdomains with crucial functions. Caveolae, small pits in the plasma …

A new aspect of cell membrane structure is presented, based on the dynamic clustering of
sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed …

Endocytic mechanisms control the lipid and protein composition of the plasma membrane,
thereby regulating how cells interact with their environments. Here, we review what is known …

Signal transduction is initiated by complex protein–protein interactions between ligands,
receptors and kinases, to name only a few. It is now becoming clear that lipid micro …

▪ Abstract Recent studies showing that detergent-resistant membrane fragments can be
isolated from cells suggest that biological membranes are not always in a liquid-crystalline …

Lipid rafts are subdomains of the plasma membrane that contain high concentrations of
cholesterol and glycosphingolipids. They exist as distinct liquid-ordered regions of the …

The cell biology of caveolae is a rapidly growing area of biomedical research. Caveolae are
known primarily for their ability to transport molecules across endothelial cells, but modern …

Mammalian cells take up extracellular material by a variety of different mechanisms that are
collectively termed endocytosis. Endocytic mechanisms serve many important cellular …

Endothelial cells play a major part in the regulation of vascular permeability and
angiogenesis. According to their duty to fit the needs of the underlying tissue, endothelial …