Solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl amino acids
GB Fields, RL Noble - … journal of peptide and protein research, 1990 - Wiley Online Library
9‐Fluorenylmethoxycarbonyl (Fmoc) amino acids were first used for solid phase peptide
synthesis a little more than a decade ago. Since that time, Fmoc solid phase peptide …
synthesis a little more than a decade ago. Since that time, Fmoc solid phase peptide …
Amino acid-protecting groups
A Isidro-Llobet, M Alvarez, F Albericio - Chemical reviews, 2009 - ACS Publications
Synthetic organic chemistry is based on the concourse of reagents and catalysts to achieve
the clean formation of new bonds, and appropriate protecting groups are required to prevent …
the clean formation of new bonds, and appropriate protecting groups are required to prevent …
Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences
I Coin, M Beyermann, M Bienert - Nature protocols, 2007 - nature.com
This protocol for solid-phase peptide synthesis (SPPS) is based on the widely used
Fmoc/tBu strategy, activation of the carboxyl groups by aminium-derived coupling reagents …
Fmoc/tBu strategy, activation of the carboxyl groups by aminium-derived coupling reagents …
[КНИГА][B] Chemical approaches to the synthesis of peptides and proteins
P Lloyd-Williams, F Albericio, E Giralt - 2020 - taylorfrancis.com
Organic chemists working on the synthesis of natural products have long found a special
challenge in the preparation of peptides and proteins. However, more reliable, more efficient …
challenge in the preparation of peptides and proteins. However, more reliable, more efficient …
Limiting racemization and aspartimide formation in microwave‐enhanced Fmoc solid phase peptide synthesis
SA Palasek, ZJ Cox, JM Collins - Journal of peptide science: an …, 2007 - Wiley Online Library
Microwave energy represents an efficient manner to accelerate both the deprotection and
coupling reactions in 9‐fluorenylmethyloxycarbonyl (Fmoc) solid phase peptide synthesis …
coupling reactions in 9‐fluorenylmethyloxycarbonyl (Fmoc) solid phase peptide synthesis …
Replacing DMF in solid-phase peptide synthesis: varying the composition of green binary solvent mixtures as a tool to mitigate common side-reactions
S Jadhav, V Martin, PHG Egelund, HJ Castro… - Green …, 2021 - pubs.rsc.org
Significant efforts have been made in recent years to identify more environmentally benign
and less hazardous alternatives to N, N-dimethylformamide (DMF) in solid-phase peptide …
and less hazardous alternatives to N, N-dimethylformamide (DMF) in solid-phase peptide …
Sequence dependence of aspartimide formation during 9-fluorenylmethoxycarbonyl solid-phase peptide synthesis
We have examined the sequence dependence of aspartimide formation during Fmoc-based
solid-phase synthesis of the peptide Val-Lys-Asp-X-Tyr-Ile. The extent of aspartimide …
solid-phase synthesis of the peptide Val-Lys-Asp-X-Tyr-Ile. The extent of aspartimide …
Aspartimide formation in peptide chemistry: occurrence, prevention strategies and the role of N-hydroxylamines
Many side reactions may occur at various stages of solid-phase or solution peptide
synthesis. 1 Some of these take place during activation of the C-terminus and coupling with …
synthesis. 1 Some of these take place during activation of the C-terminus and coupling with …
Boosting Fmoc solid-phase peptide synthesis by ultrasonication
We investigated the ultrasonication-mediated effects on the Fmoc-based solid-phase
peptide synthesis (SPPS). Our study culminated with the development of an ultrasound …
peptide synthesis (SPPS). Our study culminated with the development of an ultrasound …
Squaring the Circle in Peptide Assembly: From Fibers to Discrete Nanostructures by de Novo Design
The design of bioinspired nanostructures and materials of defined size and shape is
challenging as it pushes our understanding of biomolecular assembly to its limits. In such …
challenging as it pushes our understanding of biomolecular assembly to its limits. In such …