Solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl amino acids

GB Fields, RL Noble - … journal of peptide and protein research, 1990 - Wiley Online Library
9‐Fluorenylmethoxycarbonyl (Fmoc) amino acids were first used for solid phase peptide
synthesis a little more than a decade ago. Since that time, Fmoc solid phase peptide …

Amino acid-protecting groups

A Isidro-Llobet, M Alvarez, F Albericio - Chemical reviews, 2009 - ACS Publications
Synthetic organic chemistry is based on the concourse of reagents and catalysts to achieve
the clean formation of new bonds, and appropriate protecting groups are required to prevent …

Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences

I Coin, M Beyermann, M Bienert - Nature protocols, 2007 - nature.com
This protocol for solid-phase peptide synthesis (SPPS) is based on the widely used
Fmoc/tBu strategy, activation of the carboxyl groups by aminium-derived coupling reagents …

[КНИГА][B] Chemical approaches to the synthesis of peptides and proteins

P Lloyd-Williams, F Albericio, E Giralt - 2020 - taylorfrancis.com
Organic chemists working on the synthesis of natural products have long found a special
challenge in the preparation of peptides and proteins. However, more reliable, more efficient …

Limiting racemization and aspartimide formation in microwave‐enhanced Fmoc solid phase peptide synthesis

SA Palasek, ZJ Cox, JM Collins - Journal of peptide science: an …, 2007 - Wiley Online Library
Microwave energy represents an efficient manner to accelerate both the deprotection and
coupling reactions in 9‐fluorenylmethyloxycarbonyl (Fmoc) solid phase peptide synthesis …

Replacing DMF in solid-phase peptide synthesis: varying the composition of green binary solvent mixtures as a tool to mitigate common side-reactions

S Jadhav, V Martin, PHG Egelund, HJ Castro… - Green …, 2021 - pubs.rsc.org
Significant efforts have been made in recent years to identify more environmentally benign
and less hazardous alternatives to N, N-dimethylformamide (DMF) in solid-phase peptide …

Sequence dependence of aspartimide formation during 9-fluorenylmethoxycarbonyl solid-phase peptide synthesis

JL Lauer, CG Fields, GB Fields - Letters in peptide science, 1995 - Springer
We have examined the sequence dependence of aspartimide formation during Fmoc-based
solid-phase synthesis of the peptide Val-Lys-Asp-X-Tyr-Ile. The extent of aspartimide …

Aspartimide formation in peptide chemistry: occurrence, prevention strategies and the role of N-hydroxylamines

R Subiros-Funosas, A El-Faham, F Albericio - Tetrahedron, 2011 - Elsevier
Many side reactions may occur at various stages of solid-phase or solution peptide
synthesis. 1 Some of these take place during activation of the C-terminus and coupling with …

Boosting Fmoc solid-phase peptide synthesis by ultrasonication

F Merlino, S Tomassi, AM Yousif, A Messere… - Organic …, 2019 - ACS Publications
We investigated the ultrasonication-mediated effects on the Fmoc-based solid-phase
peptide synthesis (SPPS). Our study culminated with the development of an ultrasound …

Squaring the Circle in Peptide Assembly: From Fibers to Discrete Nanostructures by de Novo Design

AL Boyle, EHC Bromley, GJ Bartlett… - Journal of the …, 2012 - ACS Publications
The design of bioinspired nanostructures and materials of defined size and shape is
challenging as it pushes our understanding of biomolecular assembly to its limits. In such …