Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …

Deep learning generative approaches provide an opportunity to broadly explore protein
structure space beyond the sequences and structures of natural proteins. Here, we use deep …

Influenza vaccines that confer broad and durable protection against diverse viral strains
would have a major effect on global health, as they would lessen the need for annual …

The prediction of protein three-dimensional structure from amino acid sequence has been a
grand challenge problem in computational biophysics for decades, owing to its intrinsic …

Engineered proteins offer the potential to solve many problems in biomedicine, energy, and
materials science, but creating designs that succeed is difficult in practice. A significant …

Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

The coronavirus disease pandemic of 2019 (COVID-19) caused by the novel SARS-CoV-2
coronavirus resulted in economic losses and threatened human health worldwide. The …

Many biological investigations require 3D imaging of cells or tissues with nanoscale spatial
resolution. We recently discovered that preserved biological specimens can be physically …

Metal–organic polyhedra are a member of metal–organic materials, and are together with
metal–organic frameworks utilized as emerging porous platforms for numerous applications …