Abstract Activating transcription factor 4 (ATF4), a member of the ATF/cAMP response
element-binding (CREB) family, plays a critical role as a stress-induced transcription factor. It …

Ferroptosis is a nonapoptotic form of cell death characterized by iron dependence and lipid
peroxidation. Ferroptosis is involved in a range of pathological processes, such as cancer …

Diabetes significantly increases the risk of heart failure by inducing myocardial cell death,
potentially through ferroptosis—an iron-dependent, non-apoptotic cell death pathway …

Alkaloids have remarkable biological and pharmacological properties and have recently
garnered extensive attention. Various alkaloids, including commercially available drugs …

The activating transcription factor (ATF)/cAMP-response element binding protein (CREB)
family represents a large group of basic zone leucine zip (bZIP) transcription factors (TFs) …

Pancreatic cancer is an aggressive disease with a 5 year survival rate of 13%. This poor
survival is attributed, in part, to limited and ineffective treatments for patients with metastatic …

Pancreatic cancer (PC) is one of the most lethal malignancies and new therapeutic
strategies are urgently needed. β1, 3-N-acetylglucosaminyltransferase V (B3GNT5) may be …

Background Pancreatic cancer is a highly aggressive and lethal disease with limited
treatment options. In this study, we investigated the potential therapeutic effects of …

Ageing is inherent to all human beings, most mechanistic explanations of ageing results
from the combined effects of various physiological and pathological processes. Additionally …

Studies suggest steroidal alkaloids contribute to the health properties of tomato-rich diets.
Untargeted studies have detected tomato steroidal alkaloid metabolites in plasma, tissues …