[HTML][HTML] The central role of IL-33/IL-1RL1 pathway in asthma: from pathogenesis to intervention
AKS Jayalatha, L Hesse, ME Ketelaar… - Pharmacology & …, 2021 - Elsevier
Abstract Interleukin-33 (IL-33), a member of the IL-1 family, and its cognate receptor,
Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma …
Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma …
Decoding the genetic and epigenetic basis of asthma
Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank
K Valette, Z Li, V Bon-Baret, A Chignon… - Communications …, 2021 - nature.com
To identify candidate causal genes of asthma, we performed a genome-wide association
study (GWAS) in UK Biobank on a broad asthma definition (n= 56,167 asthma cases and …
study (GWAS) in UK Biobank on a broad asthma definition (n= 56,167 asthma cases and …
A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
D Smith, H Helgason, P Sulem, US Bjornsdottir… - PLoS …, 2017 - journals.plos.org
IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and
has emerged as a promising new drug target for asthma and allergic disease. Common …
has emerged as a promising new drug target for asthma and allergic disease. Common …
Interleukin-4 and interferon-γ orchestrate an epithelial polarization in the airways
Abstract Interferon-γ (IFN-γ) and interleukin-4 (IL-4) are key effector cytokines for the
differentiation of T helper type 1 and 2 (Th1 and Th2) cells. Both cytokines induce fate …
differentiation of T helper type 1 and 2 (Th1 and Th2) cells. Both cytokines induce fate …
A review on the pathophysiology of asthma remission
Asthma is a chronic respiratory condition, which is highly prevalent worldwide. Although no
cure is currently available, it is well recognized that some asthma patients can …
cure is currently available, it is well recognized that some asthma patients can …
[HTML][HTML] IL1RL1 asthma risk variants regulate airway type 2 inflammation
Genome-wide association studies of asthma have identified genetic variants in the IL1RL1
gene, but the molecular mechanisms conferring risk are unknown. IL1RL1 encodes the ST2 …
gene, but the molecular mechanisms conferring risk are unknown. IL1RL1 encodes the ST2 …
[HTML][HTML] Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium
Abstract The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the
contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma …
contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma …
Transcriptome analysis of CD4+ T cells in coeliac disease reveals imprint of BACH2 and IFNγ regulation
EM Quinn, C Coleman, B Molloy, P Dominguez Castro… - PloS one, 2015 - journals.plos.org
Genetic studies have to date identified 43 genome wide significant coeliac disease
susceptibility (CD) loci comprising over 70 candidate genes. However, how altered …
susceptibility (CD) loci comprising over 70 candidate genes. However, how altered …
Advances and highlights in mechanisms of allergic disease in 2015
This review highlights some of the advances in mechanisms of allergic disease, particularly
anaphylaxis, including food allergy, drug hypersensitivity, atopic dermatitis (AD), allergic …
anaphylaxis, including food allergy, drug hypersensitivity, atopic dermatitis (AD), allergic …