Ovarian damage from chemotherapy and current approaches to its protection

N Spears, F Lopes, A Stefansdottir… - Human reproduction …, 2019 - academic.oup.com
Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

The role of oxidative stress and natural antioxidants in ovarian aging

L Yang, Y Chen, Y Liu, Y **ng, C Miao… - Frontiers in …, 2021 - frontiersin.org
The ovarian system comprises vital organs in females and is of great significance for the
maintenance of reproductive potential and endocrine stability. Although complex …

Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells

Y Chen, Y Zhao, C Miao, L Yang, R Wang… - Journal of ovarian …, 2022 - Springer
Background Exposure to cyclophosphamide (CTX) induces premature ovarian insufficiency
(POI). Quercetin is a natural flavonoid that exhibits anti-inflammatory and antioxidant …

Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide …

S Zheng, M Ma, Y Chen, M Li - Basic & Clinical Pharmacology …, 2022 - Wiley Online Library
To investigate the ability of quercetin to improve ovarian function and inhibit ovarian
oxidative stress through the PI3K/Akt/FoxO3a signalling pathway in a rat model of premature …

Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM …

S Liu, Y Wang, H Yang, J Tan, J Zhang, D Zi - Stem Cell Research & …, 2024 - Springer
Background DNA damage and oxidative stress induced by chemotherapy are important
factors in the onset of premature ovarian insufficiency (POI). Studies have shown that …

Alhagi honey polysaccharides attenuate intestinal injury and immune suppression in cyclophosphamide-induced mice

G Cai, Y Wu, A Wusiman, P Gu, N Mao, S Xu, T Zhu… - Food & function, 2021 - pubs.rsc.org
Cyclophosphamide (CY), extensively used as an anti-cancer agent, could cause diverse
side effects, such as immunosuppression and intestinal barrier damage. Alhagi honey …

[HTML][HTML] Effects of natural capsicum extract on growth performance, nutrient utilization, antioxidant status, immune function, and meat quality in broilers

SJ Liu, J Wang, TF He, HS Liu, XS Piao - Poultry science, 2021 - Elsevier
This research was conducted to determine the effects of natural capsaicin extract (NCE) as
an alternative to the antibiotic (chlortetracycline, CTC) on growth performance, antioxidant …

LCZ696 (sacubitril/valsartan) mitigates cyclophosphamide-induced premature ovarian failure in rats; the role of TLR4/NF-κB/NLRP3/Caspase-1 signaling pathway

WAI Khallaf, EE Sharata, ME Attya, AM Abo-Youssef… - Life Sciences, 2023 - Elsevier
Aim Cyclophosphamide (CP) is used to treat a variety of cancers and autoimmune illnesses.
CP has been found to frequently cause premature ovarian failure (POF). The study's …

Curcumin as a preventive or therapeutic measure for chemotherapy and radiotherapy induced adverse reaction: A comprehensive review

S Akbari, E Kariznavi, M Jannati, S Elyasi… - Food and Chemical …, 2020 - Elsevier
Curcumin has attracted much attention for medicinal purposes in wide range of illnesses
including cancer. In some studies, its efficacy is evaluated against chemotherapy and …

**feng pills ameliorate premature ovarian insufficiency induced by cyclophosphamide in rats and correlate to modulating IL-17A/IL-6 axis and MEK/ERK signals

Y Hu, R Zhong, X Guo, G Li, J Zhou, W Yang… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance **feng Pill (JFP) is a classical Chinese medicine
formula and composed of 9 herbs, including Epimedium brevicornu Maxim (Yinyanghuo) …