The plasminogen activator (PA) system is an extracellular proteolytic enzyme system
associated with various physiological and pathophysiological processes. A large body of …

New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor
growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has …

Abstract p53 limits the proliferation of primary diploid fibroblasts by inducing a state of
growth arrest named replicative senescence—a process which protects against oncogenic …

Osteosarcoma is the most common primary malignancy of bone. It arises in bone during
periods of rapid growth and primarily affects adolescents and young adults. The 5‐year …

Cancer is the final result of uninhibited cell growth that involves an enormous group of
associated diseases. One major aspect of cancer is when cells attack adjacent components …

Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or
young adults. It is the second highest cause of cancer-related death in these age groups …

The urokinase plasminogen activator (uPA) system (uPAS) consists of the uPA, its cognate
receptor (uPAR) and two specific inhibitors, the plasminogen activator inhibitor 1 (PAI-1) and …

In recent years the discovery of cancer biomarkers has become a major focus of cancer
research. The widespread use of prostate-specific antigen in prostate cancer screening has …

Tissue kallikreins are members of the S1 family (clan SA) of trypsin-like serine proteases
and are present in at least six mammalian orders. In humans, tissue kallikreins (hK) are …

Clinical cancer proteomics aims at the identification of markers for early detection and
predictive purposes, as well as to provide novel targets for drug discovery and therapeutic …