From bacteria to humans, cells secrete a large variety of membrane-bound extracellular
vesicles. Only relatively recently has it however started to become clear that the exovesicular …

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

The nematode Caenorhabditis elegans is a powerful experimental setting for uncovering
fundamental tenets of nervous system organization and function. Its nearly invariant and …

The life cycle of a primary cilium begins in quiescence and ends prior to mitosis. In quiescent
cells, the primary cilium insulates itself from contiguous dynamic membrane processes on …

ABSTRACT Introduction: Extracellular vesicles (EVs) represent an important mode of
intercellular communication. There is now a growing awareness that predominant EV …

Animals face both external and internal dangers: pathogens threaten from the environment,
and unstable genomic elements threaten from within. C. elegans protects itself from …

Extracellular vesicles (EVs) may mediate intercellular communication by carrying protein
and RNA cargo. The composition, biology, and roles of EVs in physiology and pathology …

Ciliary extracellular vesicle (EV) shedding is evolutionarily conserved. In Chlamydomonas
and C. elegans, ciliary EVs act as signaling devices. 1–3 In cultured mammalian cells, ciliary …

Highlights•Extracellular vesicles (EVs) deliver a set of biomolecules including regulatory
RNAs and proteins between neural cells.•EVs are suggested to play a role in CNS …

Primary cilia project from the surface of most vertebrate cells and are key in sensing
extracellular signals and locally transducing this information into a cellular response. Recent …